2. Gene
  3. NUMBL - NUMB like endocytic adaptor protein Gene

NUMBL - NUMB like endocytic adaptor protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE

Gene ID: 9253 | Gene type: protein coding

About NUMBL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,665,905-40,690,651 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 8.6), endometrium (RPKM 7.2) and 25 other tissues.

Summary

Involved in cytokine-mediated signaling pathway and protein metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NUMBL Products(3)

mRNA Protein Name
NM_001289979.2 NP_001276908.1 numb-like protein isoform b
NM_001289980.2 NP_001276909.1 numb-like protein isoform b
NM_004756.5 NP_004747.1 numb-like protein isoform a

NUMBL Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (80 - 201)

NumbF

NumbF: NUMB domain (287 - 372)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 609 a.a.
Protein Preferred Names Protein Names

numb-like protein

numb homolog-like

Related Diseases

Diseases Alias
Differentiating Neuroblastoma
Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09682 NUMBL Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NUMBL VGNC VGNC:32349
Macaca mulatta NUMBL VGNC VGNC:75558
Rattus norvegicus NUMBL RGD RGD:1307579
Canis familiaris NUMBL VGNC VGNC:44043
Mus musculus NUMBL MGD MGI:894702
Felis catus NUMBL VGNC VGNC:68597