Bag3 - BCL2-associated athanogene 3 Gene

Also Known as Bis; mg638

Species: Mus musculus

Gene Type: protein coding
Gene ID: 29810

Summary

Predicted to enable adenyl-nucleotide exchange factor activity and chaperone binding activity. Involved in muscle cell cellular homeostasis. Acts upstream of or within several processes, including cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; and protein stabilization. Located in Z disc. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study dilated cardiomyopathy 1HH. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Apr 2022]

Bag3 Products (1)

mRNA Protein Name
NM_013863.5 NP_038891.4 BAG family molecular chaperone regulator 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11527400 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20884878 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within cellular response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
16936253 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
11527400 MGI
involved in muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
16936253 MGI
acts upstream of or within negative regulation of striated muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16936253 MGI
acts upstream of or within protein stabilization IMP
IMP: Inferred from mutant phenotype
20884878 MGI
acts upstream of striated muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16936253 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in Z disc IDA
IDA: Inferred from direct assay
16936253 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BAG family molecular chaperone regulator 3

  • BAG-3

  • Bcl-2-binding protein Bis

  • Bcl-2-interacting death suppressor

  • bcl-2-associated athanogene 3

Bag3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Bag3 Q9JLV1 EBNA-LP Epstein-Barr virus Q8AZK7
Anti Bait CoIP
18457437
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Bag3 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71848 BAG-3 Protein, Mouse (P.pastoris, His) Q9JLV1 (S2-P577) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-117282 JG-98 99.88% Unkown
HY-156278 FB49 Inhibitor 99.76% Unkown
HY-170944 BAG3/HSP70-IN-1 / Unkown
HY-180948 PZ-11 Inducer / Unkown
HY-RS01344 BAG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17327 Bag3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23782 Bag3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P992379 IB001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bag3 NCBI NCBI:9531