NBR1 - NBR1 autophagy cargo receptor Gene

Also Known as IAI3B; M17S2; MIG19; 1A1-3B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4077

About NBR1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,170,409-43,211,688 (from NCBI)

This gene has 7 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in testis (RPKM 41.5), thyroid (RPKM 32.2) and 25 other tissues.

Summary

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian Cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific Autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

NBR1 Products (4)

mRNA	Protein	Name
NM_001291571.2	NP_001278500.1	next to BRCA1 gene 1 protein isoform b
NM_001291572.2	NP_001278501.1	next to BRCA1 gene 1 protein isoform c
NM_005899.5	NP_005890.2	next to BRCA1 gene 1 protein isoform a
NM_031862.4	NP_114068.1	next to BRCA1 gene 1 protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19250911	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	19427866	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in macroautophagy	IDA IDA: Inferred from direct assay	19250911	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytosol	IDA IDA: Inferred from direct assay	19250911	GOA
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	21296869	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	19250911	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NBR1 Protein Structure

PB1

0
200
400
600
800
966 a.a.

Protein Preferred Names	Protein Names
next to BRCA1 gene 1 protein	B-box protein

NBR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NBR1	Q14596	GSK3A	Homo sapiens	P49840	Pull Down	20368287
Intra	NBR1	Q14596	GSK3A	Homo sapiens	P49840	BioID	34524948
Intra	NBR1	Q14596	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	19250911
Intra	NBR1	Q14596	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Cross	NBR1	Q14596	ATG8	Saccharomyces cerevisiae	P38182	Pull Down	19250911
Cross	NBR1	Q14596	ATG8	Saccharomyces cerevisiae	P38182	Y2H	19250911
Intra	NBR1	Q14596	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	19250911
Intra	NBR1	Q14596	SQSTM1	Homo sapiens	Q13501	Confocal	19250911
Intra	NBR1	Q14596	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	19250911
Intra	NBR1	Q14596	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	NBR1	Q14596	GABARAP	Homo sapiens	O95166	Pull Down	19250911
Intra	NBR1	Q14596	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	NBR1	Q14596	GABARAPL2	Homo sapiens	P60520	Y2H	19250911
Intra	NBR1	Q14596	GABARAPL2	Homo sapiens	P60520	Pull Down	19250911
Intra	NBR1	Q14596	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	NBR1	Q14596	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	NBR1	Q14596	SYT4	Homo sapiens	Q9H2B2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

NBR1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P85774	NBR1 Antibody (YA5466)	ICC/IF, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Myopathy, Myofibrillar, 9, With Early Respiratory Failure	Hereditary Myopathy With Early Respiratory Failure Hmerf Myopathy, Proximal, With Early Respiratory Muscle Involvement Edstrom Myopathy Mfm-Titinopathy MFM9 Mprm Hereditary Inclusion Body Myopathy With Early Respiratory Failure Hibm-Erf Myofibrillar Myopathy-Titinopathy Myofibrillar Myopathy With Early Respiratory Failure Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant Myofibrillar Myopathy 9 Myofibrillar Myopathy 9 With Early Respiratory Failure Autosomal Dominant Distal Myopathy With Early Respiratory Failure Proximal Myopathy With Early Respiratory Muscle Involvement Hereditary Proximal Myopathy With Early Respiratory Failure Admerf Edström Myopathy Hmerf-Erf
Vici Syndrome	Absent Corpus Callosum Cataract Immunodeficiency VICIS Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum Dionisi Vici Sabetta Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome Dionisi-Vici-Sabetta-Gambarara Syndrome Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Brooke-Spiegler Syndrome	Cyld Cutaneous Syndrome Spiegler-Brooke Syndrome Familial Cylindromatosis BRSS Bss Sbs Multiple Familial Trichoepithelioma Ancell-Spiegler Cylindromas Familial Multiple Trichoepithelioma Trichoepithelioma Fc Mft Multiple Familial Trichoepitheliomas Ccs Turban Tumor Syndrome Schilbach-Rott Syndrome Eccrine Dermal Cylindroma Familial Multiple Trichoepitheliomata
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-146130	ATG7-IN-2	Inhibitor	99.32%	Unkown
HY-146131	ATG7-IN-3	Inhibitor	99.26%	Unkown
HY-RS09061	NBR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17332	Nbr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23787	Nbr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NBR1	RGD	RGD:69195
Macaca mulatta	NBR1	VGNC	VGNC:75067
Canis familiaris	NBR1	VGNC	VGNC:43634
Felis catus	NBR1	VGNC	VGNC:68118
Mus musculus	NBR1	MGD	MGI:108498
Bos taurus	NBR1	VGNC	VGNC:31896
Others	NBR1	NCBI