SYT4 - synaptotagmin 4 Gene

Also Known as HsT1192

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6860

About SYT4

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:43,267,892-43,277,490 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 31 paralogues. Biased expression in brain (RPKM 34.8), adrenal (RPKM 10.3) and 1 other tissue.

Summary

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in negative regulation of Catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in several cellular components, including microvesicle; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including axon; exocytic vesicle; and glutamatergic synapse. Predicted to be integral component of neuronal dense core vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYT4 Products (1)

mRNA	Protein	Name
NM_020783.4	NP_065834.1	synaptotagmin-4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of catecholamine secretion	IGI IGI: Inferred from genetic interaction	20735850	GOA
involved in positive regulation of dendrite extension	IDA IDA: Inferred from direct assay	23999003	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT4 Protein Structure

C2

0
100
200
300
400
425 a.a.

Protein Preferred Names	Protein Names
synaptotagmin-4	synaptotagmin IV

SYT4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYT4	Q9H2B2	NBR1	Homo sapiens	Q14596-2	Y2H Prey Pooling	32296183
Intra	SYT4	Q9H2B2	NBR1	Homo sapiens	Q14596-2	Y2H Array	32296183
Intra	SYT4	Q9H2B2	NDUFA12	Homo sapiens	Q9UI09	Validated Y2H	32296183
Intra	SYT4	Q9H2B2	NDUFA12	Homo sapiens	Q9UI09	Y2H Array	32296183
Intra	SYT4	Q9H2B2	NDUFA12	Homo sapiens	Q9UI09	Y2H Prey Pooling	32296183
Intra	SYT4	Q9H2B2	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	SYT4	Q9H2B2	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	SYT4	Q9H2B2	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	SYT4	Q9H2B2	NBR1	Homo sapiens	Q14596	Y2H Array	25416956
Intra	SYT4	Q9H2B2	NBR1	Homo sapiens	Q14596	Validated Y2H	25416956
Intra	SYT4	Q9H2B2	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	SYT4	Q9H2B2	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14116	SYT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SYT4	VGNC	VGNC:78076
Felis catus	SYT4	VGNC	VGNC:80495
Rattus norvegicus	SYT4	RGD	RGD:68397
Canis familiaris	SYT4	VGNC	VGNC:47047
Bos taurus	SYT4	VGNC	VGNC:35543
Mus musculus	SYT4	MGD	MGI:101759
Others	SYT4	NCBI