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P2RY11 - purinergic receptor P2Y11 Gene

Also Known as P2Y11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5032

About P2RY11

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,111,693-10,115,372 (from NCBI)

This gene has 2 transcripts (splice variants), 145 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 6.0), lymph node (RPKM 4.7) and 25 other tissues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

P2RY11 Products (1)

mRNA	Protein	Name
NM_002566.5	NP_002557.2	P2Y purinoceptor 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables G protein-coupled ATP receptor activity	IDA IDA: Inferred from direct assay	18048695	GOA
enables neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	18048695	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18048695	GOA
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	18048695	GOA
involved in cellular response to ATP	IDA IDA: Inferred from direct assay	18048695	GOA
involved in neuronal signal transduction	IDA IDA: Inferred from direct assay	18048695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY11 Protein Structure

7tm_1

0
100
200
300
374 a.a.

Protein Preferred Names	Protein Names
P2Y purinoceptor 11	purinergic receptor P2Y, G-protein coupled, 11

Related Diseases

Diseases	Alias
Recurrent Hypersomnia	Primary Recurrent Hypersomnia Hypersomnia Recurrent Disorders Of Excessive Somnolence Hypersomnia, Recurrent
Narcolepsy 1	NRCLP1 Narcoleptic Syndrome 1 Gelineau Disease Narcolepsy-Cataplexy Narcolepsy-Cataplexy Syndrome Narcolepsy, Type 1 Narcolepsy Type 1 Cataplexy Gélineau'S Syndrome Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Kleine-Levin Hibernation Syndrome	Kleine-Levin Syndrome Familial Kleine-Levin Syndrome Kleine Levin Syndrome Familial Hibernation Syndrome Recurrent Hypersomnolence Hypersomnia-Bulimia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09918	P2RY11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	P2RY11	VGNC	VGNC:106855
Canis familiaris	P2RY11	VGNC	VGNC:108251
Rattus norvegicus	P2RY11	RGD	RGD:7666983
Others	P2RY11	NCBI