RSF1 - remodeling and spacing factor 1 Gene

Also Known as XAP8; p325; HBXAP; RSF-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51773

About RSF1

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:77,660,009-77,872,232 (from NCBI)

This gene has 12 transcripts (splice variants), 258 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 7.3), thyroid (RPKM 7.0) and 25 other tissues.

Summary

This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

RSF1 Products (1)

mRNA Protein Name
NM_016578.4 NP_057662.3 remodeling and spacing factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
NOT enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
12972596 GOA
enables histone binding IDA
IDA: Inferred from direct assay
12972596 GOA
enables histone octamer slider activity IDA
IDA: Inferred from direct assay
9836642 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12972596 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in DNA-templated transcription initiation IDA
IDA: Inferred from direct assay
9836642 GOA
involved in chromatin organization IDA
IDA: Inferred from direct assay
11691835 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
9836642 GOA
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
12972596 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11944984 GOA
involved in nucleosome assembly EXP
EXP: Inferred from Experiment
11691835 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
12972596 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11788598 GOA
involved in positive regulation of viral transcription IDA
IDA: Inferred from direct assay
11788598 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12972596 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of RSF complex IPI
IPI: Inferred from physical interaction
9836642 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11788598 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RSF1 Protein Structure

WHIM1

WHIM1: WSTF, HB1, Itc1p, MBD9 motif 1 (99 - 147)

WSD

WSD: Williams-Beuren syndrome DDT (WSD), D-TOX E motif (150 - 182)

(188 - 409)

PHD

PHD: PHD-finger (894 - 940)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1441 a.a.
Protein Preferred Names Protein Names

remodeling and spacing factor 1

  • HBV pX-associated protein 8

RSF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RSF1 Q96T23 SMARCA5 Homo sapiens O60264
Anti Bait CoIP
12972596
Intra
RSF1 Q96T23 SMARCA5 Homo sapiens O60264
Anti Tag CoIP
12972596
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatitis B

  • Chronic Hepatitis B

  • Hepatitis B Infection

  • Serum Hepatitis

  • HBV

  • Hepatitis B Chronic

  • Hbv, Susceptibility To

  • Hepatitis B, Chronic

  • Chronic Hepatitis B Without Delta Agent

  • Chronic Hbv - [Hepatitis B Virus] Infection

  • Hepatitis B Nos

  • Chronic Type B Viral Hepatitis

  • Hep B Nos
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Ovarian Melanoma
Retinitis Pigmentosa 31

  • RP31

  • Retinitis Pigmentosa-31

  • Retinitis Pigmentosa, Type 31
Retinitis Pigmentosa 12

  • RP12

  • Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

  • Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

  • Rp With Or Without Pprpe

  • Retinitis Pigmentosa-12
Ovarian Serous Carcinoma

  • Ovarian Serous Adenocarcinoma
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12298 RSF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17142 Rsf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23589 Rsf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RSF1 RGD RGD:1311245
Felis catus RSF1 VGNC VGNC:64788
Mus musculus RSF1 MGD MGI:2682305
Macaca mulatta RSF1 VGNC VGNC:77044
Canis familiaris RSF1 VGNC VGNC:45773
Bos taurus RSF1 VGNC VGNC:34178
Others RSF1 NCBI