Birc2 - baculoviral IAP repeat-containing 2 Gene

Also Known as Api2; rIAP1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60371

About Birc2

Primary_assembly 8: 4,968,842-4,988,732 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 13 phenotypes. Biased expression in Adrenal (RPKM 363.4), Thymus (RPKM 214.6) and 9 other tissues.

Summary

Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in response to cAMP; response to ethanol; and response to hypoxia. Located in XY body; membrane raft; and nucleus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Birc2 Products (1)

mRNA Protein Name
NM_021752.3 NP_068520.2 baculoviral IAP repeat-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15590916 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in response to cAMP IEP
IEP: Inferred from expression pattern
11849428 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16687129 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
12023884 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15371238 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in XY body IDA
IDA: Inferred from direct assay
16343737 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15590916 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Birc2 Protein Structure

BIR

BIR: smart00238 (23 - 92)

BIR

BIR: smart00238 (154 - 223)

BIR

BIR: smart00238 (239 - 307)

UBA_BIRC2_3

UBA_BIRC2_3: cd14394 (361 - 407)

CARD_BIRC2_BIRC3

CARD_BIRC2_BIRC3: cd08329 (424 - 513)

RING-HC_BIRC2_3_7

RING-HC_BIRC2_3_7: cd16713 (532 - 588)

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  • 500
  • 589 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 2

  • apoptosis inhibitor 2

  • inhibitor of apoptosis protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-50685 A 410099.1 Inhibitor 99.30% Unkown
HY-RS01507 BIRC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01508 Birc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01509 Birc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01512 Birc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Birc2 NCBI NCBI:329