SLC1A2 - solute carrier family 1 member 2 Gene

Also Known as GLT1; HBGT; DEE41; EAAT2; GLT-1; EIEE41

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6506

About SLC1A2

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,251,205-35,420,507 (from NCBI)

This gene has 50 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 153.3).

Summary

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

SLC1A2 Products (15)

mRNA	Protein	Name
XM_017018136.1	XP_016873625.1	excitatory amino acid transporter 2 isoform X3
XM_047427443.1	XP_047283399.1	excitatory amino acid transporter 2 isoform X5
NM_004171.4	NP_004162.2	excitatory amino acid transporter 2 isoform 1
XM_017018139.2	XP_016873628.1	excitatory amino acid transporter 2 isoform X7
XM_017018137.2	XP_016873626.1	excitatory amino acid transporter 2 isoform X5
XM_047427437.1	XP_047283393.1	excitatory amino acid transporter 2 isoform X2
XM_017018138.2	XP_016873627.1	excitatory amino acid transporter 2 isoform X5
XM_047427438.1	XP_047283394.1	excitatory amino acid transporter 2 isoform X5
NM_001195728.3	NP_001182657.1	excitatory amino acid transporter 2 isoform 2
XM_047427436.1	XP_047283392.1	excitatory amino acid transporter 2 isoform X1
XM_011520285.2	XP_011518587.1	excitatory amino acid transporter 2 isoform X4
NM_001252652.2	NP_001239581.1	excitatory amino acid transporter 2 isoform 2
XM_047427442.1	XP_047283398.1	excitatory amino acid transporter 2 isoform X5
XM_047427440.1	XP_047283396.1	excitatory amino acid transporter 2 isoform X5
XM_047427441.1	XP_047283397.1	excitatory amino acid transporter 2 isoform X6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	7521911	GOA
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	15265858	GOA
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	26690923	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19527721	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in D-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	7521911	GOA
involved in L-glutamate import across plasma membrane	IGI IGI: Inferred from genetic interaction	20193040	GOA
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	26690923	GOA
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	15265858	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	21399631	GOA
part of membrane protein complex	IDA IDA: Inferred from direct assay	20193040	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	20193040	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15265858	GOA
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	21258616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC1A2 Protein Structure

SDF

0
100
200
300
400
500
574 a.a.

Protein Preferred Names	Protein Names
excitatory amino acid transporter 2	excitotoxic amino acid transporter 2 glutamate transporter-1 glutamate/aspartate transporter II human brain glutamate transporter sodium-dependent glutamate/aspartate transporter 2 solute carrier family 1 (glial high affinity glutamate transporter), member 2

SLC1A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SLC1A2	P43004	MAPT	Homo sapiens	P10636	Anti Bait CoIP	19527721
Intra	SLC1A2	P43004	MAPT	Homo sapiens	P10636	Pull Down	19527721

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC1A2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P811198	EAAT2 Antibody	WB, ICC/IF	Human, Mouse, Rat
HY-P82737	EAAT2 Antibody (YA2482)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dicarboxylic Aminoaciduria	Glutamate-Aspartate Transport Defect Dicarboxylicaminoaciduria DCBXA Renal Aminoacidurias
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Brain Edema	Intracranial Swelling Wet Brain Cerebral Edema
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Focal Epilepsy	Partial Epilepsy Epilepsies, Partial Localisation-Related Epilepsy
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Ischemia	Acute Coronary Syndrome
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Neuromyelitis Optica	Devic Disease Devic Syndrome Devic'S Disease Neuromyelitis Optica Spectrum Disorder Devic'S Syndrome Devic'S Neuromyelitis Optica Nmo Nmo Spectrum Disorder Neuromyelitis Optica Spectrum Disorders Devic Neuromyelitis Optica Optic-Spinal Ms Opticospinal Ms Nmosd Opticospinal Multiple Sclerosis Devic Ophthalmoneuromyelitis Optic Neuromyelitis Optic Neuroencephalomyelopathy Nmo - [Neuromyelitis Optica] Optic Neuritis With Demyelination
Episodic Ataxia, Type 6	Episodic Ataxia Type 6 EA6 Episodic Ataxia 6 Ea-6 Ataxia, Episodic, Type 6
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Migraine, Familial Hemiplegic, 2	FHM2 Mhp2 Migraine, Familial Basilar Familial Hemiplegic Migraine 2 Familial Hemiplegic Migraine-2 Familiar Basilar Migraine Migraine, Hemiplegic, Familial, Type 2
Ganglioglioma	Childhood Ganglioglioma Adult Ganglioglioma Cns Ganglioglioma Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Guam Disease Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam Als-Pdc Lytico-Bodig Disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome Parkinsonism-Dementia-Als Complex Pdals Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam Parkinson-Dementia Complex Of Guam G-Pdc Guam Parkinsonism-Dementia Complex ALS-PDC1 Als/Pdc Of Guam Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1 Amyotrophic Lateral Sclerosis, Guam Form Parkinsonian Disorders
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Non-Specific Early-Onset Epileptic Encephalopathy	Undetermined Early-Onset Epileptic Encephalopathy Non-Specific Eoee Undetermined Eoee
Familial Hemiplegic Migraine	Hemiplegic Migraine, Familial Hemiplegic-Ophthalmoplegic Migraine Fhm Hemiplegic Migraine Familial
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Episodic Ataxia	Isaacs Syndrome Neuromyotonia Isaacs' Syndrome Acquired Neuromyotonia Continuous Muscle Fiber Activity Syndrome Quantal Squander Syndrome Isaacs-Mertens Syndrome Ea Syndrome Episodic Ataxia Syndrome Isaac Syndrome Isaac'S-Merten'S Syndrome Isaac-Mertens Syndrome Peripheral Nerve Hyperexcitability Ea Ataxia, Episodic Isaacs Neuromyotonia Continuous Muscle Fibre Activity
Morphine Dependence
Encephalomalacia
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Alexander Disease	Alexander'S Disease ALXDRD Alexanders Leukodystrophy Axd Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia Alx Demyelinogenic Leukodystrophy Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration Of Astrocytes Leukodystrophy With Rosenthal Fibers Alexander Disease Type Ii Axd Type Ii Alexander Disease Type I Axd Type I Alexanders Disease Alexander'S Leukodystrophy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Congenital Granular Cell Tumor
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Developmental And Epileptic Encephalopathy 41	DEE41 Epileptic Encephalopathy, Early Infantile, 41 Eiee41 Developmental And Epileptic Encephalopathy, 41 Early Infantile Epileptic Encephalopathy 41
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Developmental And Epileptic Encephalopathy 35	DEE35 Epileptic Encephalopathy, Early Infantile, 35 Eiee35 Developmental And Epileptic Encephalopathy, 35 Early Infantile Epileptic Encephalopathy 35 Itpa-Related Encephalopathy Itpa-Related Lethal Infantile Neurological Disorder With Cataract And Cardiac Involvement Martsolf-Like Syndrome
Developmental And Epileptic Encephalopathy 24	DEE24 Epileptic Encephalopathy, Early Infantile, 24 Eiee24 Developmental And Epileptic Encephalopathy, 24 Early Infantile Epileptic Encephalopathy 24 Encephalopathy, Epileptic, Early Infantile, Type 24
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13051	SLC1A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13052	Slc1a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13053	Slc1a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC1A2	MGD	MGI:101931
Macaca mulatta	SLC1A2	VGNC	VGNC:77410
Bos taurus	SLC1A2	VGNC	VGNC:34712
Felis catus	SLC1A2	VGNC	VGNC:65230
Rattus norvegicus	SLC1A2	RGD	RGD:3697
Canis familiaris	SLC1A2	VGNC	VGNC:46262
Others	SLC1A2	NCBI