SLC22A16 - solute carrier family 22 member 16 Gene

Also Known as CT2; OAT6; OCT6; OKB1; FLIPT2; HEL-S-18; dJ261K5.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85413

About SLC22A16

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,424,687-110,476,613 (from NCBI)

This gene has 8 transcripts (splice variants), 258 orthologues and 22 paralogues. Biased expression in testis (RPKM 7.7) and bone marrow (RPKM 4.9).

Summary

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport Anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

SLC22A16 Products (1)

mRNA Protein Name
NM_033125.4 NP_149116.2 solute carrier family 22 member 16

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables amine transmembrane transporter activity IDA
IDA: Inferred from direct assay
15963465 GOA
enables carnitine transmembrane transporter activity IDA
IDA: Inferred from direct assay
12089149 GOA
enables organic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
12089149 GOA
enables spermidine transmembrane transporter activity IDA
IDA: Inferred from direct assay
20037140 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in acid secretion IDA
IDA: Inferred from direct assay
12089149 GOA
involved in carnitine transmembrane transport IDA
IDA: Inferred from direct assay
12089149 GOA
acts upstream of or within carnitine transport IDA
IDA: Inferred from direct assay
12089149 GOA
involved in carnitine transport IDA
IDA: Inferred from direct assay
12089149 GOA
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
12089149 GOA
acts upstream of or within organic cation transport IDA
IDA: Inferred from direct assay
15963465 GOA
involved in organic cation transport IDA
IDA: Inferred from direct assay
12089149 GOA
involved in single fertilization IMP
IMP: Inferred from mutant phenotype
12089149 GOA
involved in spermidine transmembrane transport IDA
IDA: Inferred from direct assay
20037140 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in membrane IDA
IDA: Inferred from direct assay
12089149 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12089149 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A16 Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (150 - 533)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 16

  • WUGSC:RG331P03.1

Related Diseases

Diseases Alias
Clear Cell Adenocarcinoma

  • Mesonephroma

  • Water-Clear Cell Adenocarcinoma

  • Adenocarcinoma, Clear Cell

  • Malignant Mesonephroma

  • Mesonephroid Clear Cell Carcinoma

  • Mesonephroma, Malignant

  • Water-Clear Cell Carcinoma

  • Wolffian Duct Neoplasm

  • Adenocarcinoma Clear Cell

  • Mesonephric Tumor
Rhizomelic Chondrodysplasia Punctata, Type 3

  • Rhizomelic Chondrodysplasia Punctata Type 3

  • RCDP3

  • Alkyldihydroxyacetonephosphate Synthase Deficiency

  • Alkylglycerone-Phosphate Synthase Deficiency

  • Agps Deficiency

  • Rhizomelic Chondrodysplasia Punctata 3

  • Chondrodysplasia Punctata, Rhizomelic, Type 3
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13069 SLC22A16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC22A16 VGNC VGNC:65241
Rattus norvegicus SLC22A16 RGD RGD:1592810
Macaca mulatta SLC22A16 VGNC VGNC:77527
Bos taurus SLC22A16 VGNC VGNC:34724
Mus musculus SLC22A16 MGD MGI:1918090
Canis familiaris SLC22A16 VGNC VGNC:46277
Others SLC22A16 NCBI