KCNK17 - potassium two pore domain channel subfamily K member 17 Gene

Also Known as TALK2; TASK4; TALK-2; TASK-4; K2p17.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89822

About KCNK17

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,299,001-39,314,419 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 14 paralogues. Broad expression in lung (RPKM 2.2), stomach (RPKM 1.6) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the family of Potassium Channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

KCNK17 Products (2)

mRNA Protein Name
NM_001135111.2 NP_001128583.1 potassium channel subfamily K member 17 isoform 2
NM_031460.4 NP_113648.2 potassium channel subfamily K member 17 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables outward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
26919430 GOA
enables potassium channel activity IDA
IDA: Inferred from direct assay
11248242 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in potassium ion transport IDA
IDA: Inferred from direct assay
11248242 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK17 Protein Structure

Ion_trans_2

Ion_trans_2: Ion channel (93 - 156)

Ion_trans_2

Ion_trans_2: Ion channel (190 - 267)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

potassium channel subfamily K member 17

  • 2P domain potassium channel Talk-2

Related Diseases

Diseases Alias
Birk-Barel Syndrome

  • Birk-Barel Mental Retardation Dysmorphism Syndrome

  • BIBARS

  • Mental Retardation With Hypotonia And Facial Dysmorphism

  • Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

  • Kcnk9 Imprinting Syndrome
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Brain Small Vessel Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07156 KCNK17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown