PGLYRP1 - peptidoglycan recognition protein 1 Gene

Also Known as PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8993

About PGLYRP1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,019,153-46,023,053 (from NCBI)

This gene has 1 transcript (splice variant), 184 orthologues and 3 paralogues. Restricted expression toward bone marrow (RPKM 135.5).

Summary

Enables peptidoglycan binding activity and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of Other organism; and response to bacterium. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

PGLYRP1 Products (1)

mRNA Protein Name
NM_005091.3 NP_005082.1 peptidoglycan recognition protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
14585845 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
26654597 GOA
enables peptidoglycan binding IDA
IDA: Inferred from direct assay
11461926 GOA
enables peptidoglycan immune receptor activity IDA
IDA: Inferred from direct assay
11461926 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
25595774 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
16354652 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
11461926 GOA
involved in detection of bacterium IDA
IDA: Inferred from direct assay
11461926 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
16354652 GOA
Cellular Component GO Annotation Evidence Verweise Source
is active in extracellular space IDA
IDA: Inferred from direct assay
14585845 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGLYRP1 Protein Structure

Amidase_2

Amidase_2: N-acetylmuramoyl-L-alanine amidase (52 - 181)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

peptidoglycan recognition protein 1

  • TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

Recombinant PGLYRP1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P78014 PGLYRP1/PGRP-S Protein, Human (HEK293, Fc) O75594 (Q22-P196) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Retinitis Pigmentosa 86

  • RP86

  • Retinitis Pigmentosa, Type 86
Immunodeficiency 60

  • Bach2-Related Immunodeficiency And Autoimmunity

  • Brida

  • Imd60
Psoriasis 4

  • PSORS4

  • Psoriasis Susceptibility 4

  • Psoriasis 4, Susceptibility To
Bacterial Infectious Disease

  • Bacterial Infections

  • Bacterial Infection Nos

  • Disease Caused By Bacteria

  • Bacterial Disease Or Disorder
Mite Infestation

  • Mite Infestations

  • Acariasis

  • Infestation By Mites Nos
Trombiculiasis
Parasitic Ectoparasitic Infectious Disease

  • Ectoparasitic Infestations

  • Ectoparasitism
Trench Fever

  • His-Werner Disease

  • Quintan Fever

  • Shin Bone Fever

  • Wolhynian Fever

  • Tibialgic Fever

  • Bartonellosis Due To Bartonella Quintana Infection

  • Febris Quintata

  • Five Day Fever

  • Fever Due To Rickettsia Quintana

  • Febris Quintana

  • Fever Due To Bartonella Quintana

  • Fever Due To Rochalimaea Quintana

  • Meuse Fever
Cicatricial Entropion
Sveinsson Chorioretinal Atrophy

  • SCRA

  • Atrophia Areata

  • Helicoid Peripapillary Chorioretinal Degeneration

  • Hpcd

  • Aa

  • Peripapillary Chorioretinal Degeneration, Icelandic Type

  • Helicoidal Peripapillary Chorioretinal Degeneration

  • Atrophy, Chorioretinal, Sveinsson
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10387 PGLYRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19093 Pglyrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25583 Pglyrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PGLYRP1 MGD MGI:1345092
Macaca mulatta PGLYRP1 VGNC VGNC:75968
Bos taurus PGLYRP1 VGNC VGNC:32791
Rattus norvegicus PGLYRP1 RGD RGD:621429
Felis catus PGLYRP1 VGNC VGNC:68817
Canis familiaris PGLYRP1 VGNC VGNC:44461
Others PGLYRP1 NCBI