Art. -Nr.: HY-128850

N-Acetyl-D-mannosamine

(Synonyms: N-Acetylmannosamine; ManNAc)

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N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders.

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Reinheit: 99.94%
CAS. Nr.: 3615-17-6
Formel: C₈H₁₅NO₆
Molecular Weight:221.21

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

N-Acetyl-D-mannosamine Chemical Structure

CAS. Nr.: 3615-17-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vivo

N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 1%, p.o., once daily for 16 weeks) can prevent obesity-induced hypertension in a high-fat diet-induced hypertensive mouse model by increasing the sialylation level of IgG glycans^[3].
N-Acetyl-D-mannosamine (administered orally in drinking water at a dose of 2 g/kg, 4-6 mL per day, for 12 weeks) can reverse the reduction in sialylation in the kidneys and muscles of a GNE myopathy C57BL/6J mouse model with the knock-in (Gne p.M712T) mutation^[4].
N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 0.5%, ad libitum, for 8 weeks) improves synaptic transmission and Long-Term Potentiation (LTP) in 6-month-old and 14-month-old SAMR1 mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

High-fat diet-induced hypertension C57BL/6 mice model^[2]
Dosage:

Dissolved in drinking water at a concentration of 1%
Administration:

Oral gavage (p.o.), once daily for 16 weeks
Result:

Inhibited high-fat diet-induced weight gain and increased the sialylation of IgG glycans.

Animal Model:

Knock-in C57BL/6J mice model (Gne p.M712T) of GNE myopathy
Dosage:

1 or 2 g/kg
Administration:

Administered via drinking water (4-6 mL daily), once daily for 12 weeks
Result:

Showed a significant decrease of proteinuria after only one week on the treatment (2 g/kg)

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 3615-17-6
Appearance Solid
Molecular Weight 221.21
Formel C₈H₁₅NO₆
Color White to off-white
SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C=O)NC(C)=O
Synonyms

N-Acetylmannosamine; ManNAc
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (452.06 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5206 mL

22.6030 mL

45.2059 mL

5 mM

0.9041 mL

4.5206 mL

9.0412 mL

10 mM

0.4521 mL

2.2603 mL

4.5206 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 25 mg/mL (113.01 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101. [Content Brief]

[2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778. [Content Brief]

[3]. Peng J, et al. Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. 2019 Dec 10;140(24):2005-2018. [Content Brief]

[4]. Niethamer TK, et al. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Mol Genet Metab. 2012 Dec;107(4):748-55. [Content Brief]

[5]. Taniguchi S, et al. Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse. Neurosci Lett. 2015 Jun 26;598:41-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	4.5206 mL	22.6030 mL	45.2059 mL	113.0148 mL
	5 mM	0.9041 mL	4.5206 mL	9.0412 mL	22.6030 mL
	10 mM	0.4521 mL	2.2603 mL	4.5206 mL	11.3015 mL
	15 mM	0.3014 mL	1.5069 mL	3.0137 mL	7.5343 mL
	20 mM	0.2260 mL	1.1301 mL	2.2603 mL	5.6507 mL
	25 mM	0.1808 mL	0.9041 mL	1.8082 mL	4.5206 mL
	30 mM	0.1507 mL	0.7534 mL	1.5069 mL	3.7672 mL
	40 mM	0.1130 mL	0.5651 mL	1.1301 mL	2.8254 mL
	50 mM	0.0904 mL	0.4521 mL	0.9041 mL	2.2603 mL
	60 mM	0.0753 mL	0.3767 mL	0.7534 mL	1.8836 mL
	80 mM	0.0565 mL	0.2825 mL	0.5651 mL	1.4127 mL
	100 mM	0.0452 mL	0.2260 mL	0.4521 mL	1.1301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-Acetyl-D-mannosamine

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Mouse Metabolite Compound Library

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Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

N-Acetyl-D-mannosamine

Metabolism/Protease Compound Library

Natural Product Library

Clinical Compound Library

Human Endogenous Metabolite Compound Library

Drug Repurposing Compound Library

Covalent Screening Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Glucose Metabolism Compound Library

Rare Diseases Drug Library

Human Metabolite Library

Cysteine Targeted Covalent Library

Animal-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

N-Acetyl-D-mannosamine Related Classifications

HY-128850 Related Classifications