Agrochelin, a new cytotoxic antibiotic from a marine Agrobacterium. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity

  • J Antibiot (Tokyo). 1999 Nov;52(11):983-7. doi: 10.7164/antibiotics.52.983.
C Acebal  1 ,  L M Cañedo ,  J L Puentes ,  J P Baz ,  F Romero ,  F de la Calle ,  M D Grávalos ,  P Rodriguez
Affiliations
  • 1. Instituto Biomar S.A. Pol. Ind. de Leon. Edif. CEI, Onzonilla, León, Spain.
PMID: 10656570 DOI: 10.7164/antibiotics.52.983
Abstract

Agrochelin, a new alkaloid cytotoxic substance, was produced by the fermentation of Agrobacterium sp. The compound was obtained from the Bacterial cells by solvent extraction and purified by silica gel chromatography. Agrochelin (1) and its acetyl derivative (2) exhibited cytotoxic activity.

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