Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages

  • Infect Immun. 2005 Jun;73(6):3783-6. doi: 10.1128/IAI.73.6.3783-3786.2005.
Mauro Oddo  1 ,  Thierry Calandra ,  Richard Bucala ,  Pascal R A Meylan
Affiliations
  • 1. Medical Critical Care Division, University Hospital, CH-1011 Lausanne, Switzerland. [email protected]
PMID: 15908412 DOI: 10.1128/IAI.73.6.3783-3786.2005
Abstract

Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to Bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.