Bioactive cembrane diterpenoids of Anisomeles indica

  • J Nat Prod. 2008 Jul;71(7):1207-12. doi: 10.1021/np800147z.
Yu-Li Chen  1 ,  Yu-Hsuan Lan ,  Pei-Wen Hsieh ,  Chin-Chung Wu ,  Shu-Li Chen ,  Chiao-Ting Yen ,  Fang-Rong Chang ,  Wen-Chun Hung ,  Yang-Chang Wu
Affiliations
  • 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
PMID: 18547115 DOI: 10.1021/np800147z
Abstract

Five new cembrane-type Diterpenoids with a trans-fused alpha-methylene-gamma-lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human Cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward Collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by Thrombin.