Longipetalosides A-C, new steroidal saponins from Tribulus longipetalus

  • Steroids. 2014 May;83:45-51. doi: 10.1016/j.steroids.2014.01.005.
Muhammad Akram Naveed  1 ,  Naheed Riaz  2 ,  Muhammad Saleem  1 ,  Bushra Jabeen  1 ,  Muhammad Ashraf  3 ,  Tayaba Ismail  3 ,  Abdul Jabbar  1
Affiliations
  • 1. Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
  • 2. Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan. Electronic address: [email protected].
  • 3. Department of Biochemistry and Biotechnology, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
PMID: 24530871 DOI: 10.1016/j.steroids.2014.01.005
Abstract

Longipetalosides A-C (1-3); three new furostane steroidal saponins together with (25S)-5α-furastan-3β,22,26-triol (4) and gitogenin (5) were isolated from the methanolic extract of the whole plant of Tribulus longipetalus. The structures of these compounds (1-5) were established by using 1D ((1)H, (13)C) and 2D NMR (HMQC, HMBC, COSY, NOESY) spectroscopy, and mass spectrometry (ESIMS, HRESIMS), and in comparison with literature data reported for related compounds. Compounds 1-5 were evaluated for their inhibitory activities against Enzymes α-glucosidase, Lipoxygenase, acetylcholinesterase, and butyrylcholinesterase. Only the compounds 4 and 5 were found as the inhibitors of enzyme α-glucosidase with IC50 values of 33.5±0.22 and 37.2±0.18μM, respectively.

Keywords
Enzyme inhibition; Furostane steroids; Methanolic extract; Structure elucidation; Tribulus longipetalus.
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