Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures

  • J Antibiot (Tokyo). 1994 Nov;47(11):1242-9. doi: 10.7164/antibiotics.47.1242.
C Takahashi  1 ,  A Numata ,  E Matsumura ,  K Minoura ,  H Eto ,  T Shingu ,  T Ito ,  T Hasegawa
Affiliations
  • 1. Osaka University of Pharmaceutical Sciences, Japan.
PMID: 8002386 DOI: 10.7164/antibiotics.47.1242
Abstract

Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.

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