Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase

  • Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90. doi: 10.1248/cpb.41.487.
S Kadota  1 ,  S Terashima ,  P Basnet ,  T Kikuchi ,  T Namba
Affiliations
  • 1. Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
PMID: 8477499 DOI: 10.1248/cpb.41.487
Abstract

Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol. The structures of palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (1H-1H COSY, 1H-13C COSY, 1H-13C long-range COSY, and HMBC).

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