108 Results for "

CEACAM

" in MedChemExpress (MCE) Product Catalog:
Products (108)

108 Results for "CEACAM" in MCE Product Catalog:

2
2 Cited Publications
Art. -Nr.: HY-P99051
CAS. Nr.: 2226224-30-0
Synonyms: BAY 1834942

Forschungsgebiete:  

Inflammation/Immunology Cancer

Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system .
2
2 Cited Publications
Art. -Nr.: HY-P70675
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e; CEACAM5
Species:  
Source:  
1
1 Cited Publications
Art. -Nr.: HY-P99542
CAS. Nr.: 2254086-60-5
Synonyms: SAR-408701; HuMAb2-3-SPDB-DM4

Forschungsgebiete:  

Cancer

Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 .
Art. -Nr.: HY-P99054
CAS. Nr.: 2349294-95-5
Synonyms: SAR-408377; PF-08046050 Antibody; SAR445953 Antibody

Forschungsgebiete:  

Cancer

Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542) .
Art. -Nr.: HY-177434
CAS. Nr.: 2873366-83-5
Synonyms: Precem-TcT; M 9140
Precemtabart tocentecan (Precem-TcT; M 9140) is an anti-CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) antibody-drug conjugate (ADC). Precemtabart tocentecan consists of a tumor-specific anti-CEACAM5 monoclonal antibody Precemtabart (HY-P990940), a highly hydrophilic and stable cleavable β-glucuronide linker, and a topoisomerase 1 inhibitor payload Exatecan (HY-13631), and the drug-linker conjugate for ADC is Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179). Precemtabart tocentecan inhibits the growth of CEACAM5-positive cancer cells. Precemtabart tocentecan exhibits significant antitumor activity in CEACAM5-expressing xenograft models. Precemtabart tocentecan can be used for the study of CEACAM5-expressing advanced solid tumors, especially mCRC .
Art. -Nr.: HY-163028
CAS. Nr.: 459789-75-4
Target:  

Tim3

Forschungsgebiete:  

Cancer

ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research .
Art. -Nr.: HY-P99681
CAS. Nr.: 1469876-18-3
Synonyms: IMMU 130; hMN-14-SN-38
Forschungsgebiete:  

Cancer

Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer .
Art. -Nr.: HY-P990940
CAS. Nr.: 2883118-92-9
Synonyms: MBE-748; M-9140 Antibody; MBE-2882 Antibody

Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology

HY-P990940 is an CEACAM5-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
Art. -Nr.: HY-155175
CAS. Nr.: 1113126-49-0
Reinheit:  98.93%
Target:  

Tim3 IFNAR

Forschungsgebiete:  

Cancer

TIM-3-IN-2 is a TIM-3 inhibitor. TIM-3-IN-2 blocks the interactions of TIM-3 with PtdSer, CEACAM1 and Gal-9, and inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 restores IFNγ release from peripheral blood mononuclear cells. TIM-3-IN-2 inhibits the proliferation of acute myeloid leukemia cells. TIM-3-IN-2 can be used for the research of acute myeloid leukemia .
Art. -Nr.: HY-P991060
CAS. Nr.: 1622305-37-6

Forschungsgebiete:  

Cancer

Cergutuzumab is a fully human IgG1 antibody that targets carcinoembryonic antigen (CEA, CEACAM5, CD66e). Cergutuzumab can be used to form the recombinant protein Cergutuzumab amunaleukin (HY-P99498) .
Art. -Nr.: HY-P990821

Target:  

Tim3

Forschungsgebiete:  

Inflammation/Immunology

Anti-Mouse TIM-3 Antibody (RMT3-23) is a kind of rat-derived anti-mouse TIM-3 IgG2a antibody inhibitor. Anti-Mouse TIM-3 Antibody (RMT3-23) blocks Tim-3 binding to phosphatidylserine (PtdSer) and carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). Anti-Mouse TIM-3 Antibody (RMT3-23) inhibits phagocytosis of apoptotic cells in peritoneal exudate Mac1+ cells. Anti-Mouse TIM-3 Antibody (RMT3-23) can be used for the researches of inflammation and immunology, such as rheumatoid arthritis .
Art. -Nr.: HY-P990634

Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology

NEO-201 is a humanized antibody expressed in CHO cells that targets CEACAM6/CD66c. NEO-201 features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.48 kDa. The isotype control for NEO-201 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
Art. -Nr.: HY-P990569
CAS. Nr.: 1783801-93-3
Synonyms: MK-6018

Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology

CM-24 is a humanized antibody expressed in CHO cells, targeting CEACAM1/CD66a. The predicted molecular weight (MW) of CM-24 is 145 kDa. The isotype control for CM-24 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
Art. -Nr.: HY-159884
CAS. Nr.: 328540-44-9
Target:  

Tim3 TNF Receptor IFNAR

Forschungsgebiete:  

Cancer

MG-T-19 is a potent small-molecule inhibitor targeting human TIM-3. MG-T-19 blocks the interactions between TIM-3 and its ligands such as phosphatidylserine, CEACAM1 and Galectin-9. MG-T-19 promotes the secretion of TNF-α and IFN-γ by peripheral blood mononuclear cells, and significantly enhances their ability to inhibit cancer cell proliferation. MG-T-19 can be used in studies related to acute myeloid leukemia .
Art. -Nr.: HY-P991198

Target:  

Tim3

Forschungsgebiete:  

Cancer

M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM). M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers .
Art. -Nr.: HY-RS02435
Forschungsgebiete:  

Others

CEACAM1 Human Pre-designed siRNA Set A contains three designed siRNAs for CEACAM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Art. -Nr.: HY-RS17387
Forschungsgebiete:  

Others

Ceacam1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ceacam1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Art. -Nr.: HY-P991469
Synonyms: MEDI-565

Forschungsgebiete:  

Cancer

AMG-211 (MEDI-565)i s a bispecific antibody targeting CD3E and CEACAM5/CEA/CD66e. AMG-211 can be used in Gastrointestinal cancer and Solid tumours research .
Art. -Nr.: HY-P991563

Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Others

Anti-CEACAM5 Antibody (A5B7) is a humanized antibody expressed in CHO cells, targeting CEACAM5/CEA/CD66e. Anti-CEACAM5 Antibody (A5B7) consists of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for the Anti-CEACAM5 Antibody (A5B7) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
Art. -Nr.: HY-P990852

Forschungsgebiete:  

Cancer

Anti-CEACAM7 Antibody (P3-7B) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CEACAM7. Anti-CEACAM7 Antibody (P3-7B) reacts with human carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7). Anti-CEACAM7 Antibody (P3-7B) can be used for detecting CEACAM7 in cancer.