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Art. -Nr.: HY-145111

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TNK2-IN-1

TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2574456-10-1
Formel: C₂₃H₂₄N₆O₂
Molecular Weight:416.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

TNK2-IN-1 Chemical Structure

CAS. Nr.: 2574456-10-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer^[1].

IC₅₀ & Target^[1]

TNK2

224 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	9.62 μM Compound: 39	Cytotoxicity against mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent cell viability assay Cytotoxicity against mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent cell viability assay	[PMID: 32739400]

In Vitro

TNK2-IN-1 (compound 21) has an IC₅₀ of 0.15 μM for cell viability of Ba/F3 cells expressing TNK2 D163E^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2574456-10-1
Molecular Weight 416.48
Formel C₂₃H₂₄N₆O₂
SMILES

O=C1NC2=CN=C(NC3=C(OC)C=C(CCN(C4)C)C4=C3)N=C2C5=C(N1)C=C(C)C=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li Z, et al. Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing. Bioorg Med Chem Lett. 2020 Oct 1;30(19):127456. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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