GDP-D-mannose disodium
Based on 1 Customer Validation
GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a Ki value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a Ki value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG).
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 103301-73-1
- Formula: C16H23N5Na2O16P2
- Molecular Weight:649.30
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
GDP-D-mannose disodium acts as the substrate for the GMDS/TSTA3-mediated metabolic pathway in engineered E. coli BL21 (DE3) cells to produce GDP-L-fucose[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 103301-73-1
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Appearance Solid
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Molecular Weight 649.30
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Formula C16H23N5Na2O16P2
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Color White to off-white
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SMILES
O=P(OP(OC1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)(O[Na])=O)(O[Na])OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C(N=C(N)NC4=O)=C4N=C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (154.01 mM; Need ultrasonic)
DMSO : 11.76 mg/mL (18.11 mM; ultrasonic and adjust pH to 3 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7. [Content Brief]
[3]. Cui C, et al. Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion. Nat Commun. 2025;16(1):10665. Published 2025 Nov 27. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.5401 mL | 7.7006 mL | 15.4012 mL | 38.5030 mL |
| 5 mM | 0.3080 mL | 1.5401 mL | 3.0802 mL | 7.7006 mL | |
| 10 mM | 0.1540 mL | 0.7701 mL | 1.5401 mL | 3.8503 mL | |
| 15 mM | 0.1027 mL | 0.5134 mL | 1.0267 mL | 2.5669 mL | |
| H2O | 20 mM | 0.0770 mL | 0.3850 mL | 0.7701 mL | 1.9252 mL |
| 25 mM | 0.0616 mL | 0.3080 mL | 0.6160 mL | 1.5401 mL | |
| 30 mM | 0.0513 mL | 0.2567 mL | 0.5134 mL | 1.2834 mL | |
| 40 mM | 0.0385 mL | 0.1925 mL | 0.3850 mL | 0.9626 mL | |
| 50 mM | 0.0308 mL | 0.1540 mL | 0.3080 mL | 0.7701 mL | |
| 60 mM | 0.0257 mL | 0.1283 mL | 0.2567 mL | 0.6417 mL | |
| 80 mM | 0.0193 mL | 0.0963 mL | 0.1925 mL | 0.4813 mL | |
| 100 mM | 0.0154 mL | 0.0770 mL | 0.1540 mL | 0.3850 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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