DCST1 - DC-STAMP domain containing 1 Gene

Also Known as SNKY; SPE49

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 149095

About DCST1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,033,806-155,050,930 (from NCBI)

This gene has 5 transcripts (splice variants), 178 orthologues and 3 paralogues. Biased expression in testis (RPKM 2.9), skin (RPKM 1.8) and 8 other tissues.

Summary

This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

DCST1 Products (2)

mRNA Protein Name
NM_001143687.2 NP_001137159.1 E3 ubiquitin-protein ligase DCST1 isoform 2
NM_152494.4 NP_689707.2 E3 ubiquitin-protein ligase DCST1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27782195 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
27782195 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27782195 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
27782195 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
27782195 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCST1 Protein Structure

DC_STAMP

DC_STAMP: DC-STAMP-like protein (405 - 595)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase DCST1

  • DC-STAMP domain-containing protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03588 DCST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DCST1 VGNC VGNC:61376
Mus musculus DCST1 MGD MGI:1925022
Rattus norvegicus DCST1 RGD RGD:1307756
Macaca mulatta DCST1 VGNC VGNC:71721
Bos taurus DCST1 VGNC VGNC:27923
Canis familiaris DCST1 VGNC VGNC:39812
Others DCST1 NCBI