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Cat. No.: HY-124605

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IQS-019

IQS-019 is a B cell receptor (BCR) kinase inhibitor. IQS-019 can inhibit the de-phosphorylation of constitutive and IgM-activated Syk, Lyn, and Btk. IQS-019 can inhibit cell proliferation, migration and induce apoptosis. IQS-019 exhibits antitumor activity and can be used for the research of cancer, such as B cell lymphoma.

For research use only. We do not sell to patients.

CAS No.: 1630804-24-8
Formula: C₂₅H₂₅Cl₂N₇O
Molecular Weight:510.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IQS-019 Chemical Structure

CAS No.: 1630804-24-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	GI₅₀	2.7 μM Compound: 19	Growth inhibition of human DOHH2 cells after 48 hrs by MTT assay Growth inhibition of human DOHH2 cells after 48 hrs by MTT assay	[PMID: 25222877]
DOHH-2	GI₅₀	3.7 μM Compound: 19	Growth inhibition of human DOHH2 cells after 24 hrs by MTT assay Growth inhibition of human DOHH2 cells after 24 hrs by MTT assay	[PMID: 25222877]
Granta-519	GI₅₀	3 μM Compound: 19	Growth inhibition of human GRANTA-519 cells after 48 hrs by MTT assay Growth inhibition of human GRANTA-519 cells after 48 hrs by MTT assay	[PMID: 25222877]
Granta-519	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human GRANTA-519 cells after 24 hrs by MTT assay Growth inhibition of human GRANTA-519 cells after 24 hrs by MTT assay	[PMID: 25222877]
JeKo-1	GI₅₀	3 μM Compound: 19	Growth inhibition of human JeKo1 cells after 48 hrs by MTT assay Growth inhibition of human JeKo1 cells after 48 hrs by MTT assay	[PMID: 25222877]
JeKo-1	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human JeKo1 cells after 24 hrs by MTT assay Growth inhibition of human JeKo1 cells after 24 hrs by MTT assay	[PMID: 25222877]
JVM-2	GI₅₀	3 μM Compound: 19	Growth inhibition of human JVM2 cells after 48 hrs by MTT assay Growth inhibition of human JVM2 cells after 48 hrs by MTT assay	[PMID: 25222877]
JVM-2	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human JVM2 cells after 24 hrs by MTT assay Growth inhibition of human JVM2 cells after 24 hrs by MTT assay	[PMID: 25222877]
Maver1	GI₅₀	3 μM Compound: 19	Growth inhibition of human Maver1 cells after 48 hrs by MTT assay Growth inhibition of human Maver1 cells after 48 hrs by MTT assay	[PMID: 25222877]
Maver1	GI₅₀	3.6 μM Compound: 19	Growth inhibition of human Maver1 cells after 24 hrs by MTT assay Growth inhibition of human Maver1 cells after 24 hrs by MTT assay	[PMID: 25222877]
Rec1	GI₅₀	3 μM Compound: 19	Growth inhibition of human Rec1 cells after 48 hrs by MTT assay Growth inhibition of human Rec1 cells after 48 hrs by MTT assay	[PMID: 25222877]
Rec1	GI₅₀	3.2 μM Compound: 19	Growth inhibition of human Rec1 cells after 24 hrs by MTT assay Growth inhibition of human Rec1 cells after 24 hrs by MTT assay	[PMID: 25222877]
SU-DHL-16	GI₅₀	5 μM Compound: 19	Growth inhibition of human SUDHL16 cells after 48 hrs by MTT assay Growth inhibition of human SUDHL16 cells after 48 hrs by MTT assay	[PMID: 25222877]
SU-DHL-16	GI₅₀	5.4 μM Compound: 19	Growth inhibition of human SUDHL16 cells after 24 hrs by MTT assay Growth inhibition of human SUDHL16 cells after 24 hrs by MTT assay	[PMID: 25222877]
SU-DHL-8	GI₅₀	5 μM Compound: 19	Growth inhibition of human SUDHL8 cells after 48 hrs by MTT assay Growth inhibition of human SUDHL8 cells after 48 hrs by MTT assay	[PMID: 25222877]
SU-DHL-8	GI₅₀	5.4 μM Compound: 19	Growth inhibition of human SUDHL8 cells after 24 hrs by MTT assay Growth inhibition of human SUDHL8 cells after 24 hrs by MTT assay	[PMID: 25222877]
U2932	GI₅₀	5 μM Compound: 19	Growth inhibition of human U2932 cells after 48 hrs by MTT assay Growth inhibition of human U2932 cells after 48 hrs by MTT assay	[PMID: 25222877]
U2932	GI₅₀	5.4 μM Compound: 19	Growth inhibition of human U2932 cells after 24 hrs by MTT assay Growth inhibition of human U2932 cells after 24 hrs by MTT assay	[PMID: 25222877]
WSU-NHL	GI₅₀	2.7 μM Compound: 19	Growth inhibition of human WSU-NHL cells after 48 hrs by MTT assay Growth inhibition of human WSU-NHL cells after 48 hrs by MTT assay	[PMID: 25222877]
WSU-NHL	GI₅₀	3.7 μM Compound: 19	Growth inhibition of human WSU-NHL cells after 24 hrs by MTT assay Growth inhibition of human WSU-NHL cells after 24 hrs by MTT assay	[PMID: 25222877]

Chemical Information

CAS No. 1630804-24-8
Molecular Weight 510.42
Formula C₂₅H₂₅Cl₂N₇O
SMILES

O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=C(N)N=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Balsas P, et al. Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma. J Hematol Oncol. 2017 Mar 31;10(1):80. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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