B-Raf IN 5
B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
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- CAS No.: 2648698-30-8
- Formule: C23H18ClF3N6O3S2
- Masse moléculaire:583.01
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
2.06 nM
Compound: 3b
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Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
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[PMID: 34958586] |
Chemical Information
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CAS No. 2648698-30-8
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Masse moléculaire 583.01
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Formule C23H18ClF3N6O3S2
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SMILES
O=S(C1=CC(F)=CC=C1F)(NC2=CC(Cl)=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCOC5)=N3)=C2F)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
B-Raf IN 5 Related Classifications
HY-142820 Related Classifications
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