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Cat. No.: HY-172470

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DSPE-PEG2000-GE11

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Based on 1 Customer Validation

DSPE-PEG2000-GE11 is a nanocarrier component composed of DSPE and the EGFR-targeting peptide (GE11). DSPE-PEG2000-GE11 specifically binds to EGFR and mediates receptor-mediated endocytosis of micellar drug carriers. DSPE-PEG2000-GE11 can be used for drug delivery.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 95.29%
Masse moléculaire:2000 (Average)

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DSPE-PEG2000-GE11 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

DSPE-PEG2000-GE11 mediates enhanced, EGFR-dependent cellular uptake of Doxorubicin (HY-15142A) in EGFR-positive SMMC-7721 cells, with uptake levels 1.4-fold higher than non-targeted micelles, while showing no enhanced uptake in EGFR-negative MCF-7 cells^[1].
DSPE-PEG2000-GE11 modified CUR-PTX@GE11-L inhibits HUVEC proliferation, induces G₂-M phase arrest, reduces cell migration, and alters HUVEC morphology from spread to spheroid^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DiR-loaded DSPE-PEG2000-GE11 micelles exhibit significantly enhanced tumor accumulation in EGFR-positive hepatocellular carcinoma xenografts at all measured time points up to 24 hours post-injection^[1].
DSPE-PEG2000-GE11 confers EGFR-targeted accumulation to the CUR-PTX@GE11-L liposomal formulation in subcutaneous liver cancer xenografts in nude mice, with high retention in hepatic, splenic, and pulmonary tissues^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Masse moléculaire 2000 (Average)
Color Off-white to pink
SMILES

[Mal-Cys-YHWYGYTPQNVI]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 20 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fan M, et al. Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery. J Drug Target. 2016;24(2):111-119. [Content Brief]

[2]. Tang, H., et al. Observation of antitumor mechanism of GE11-modified paclitaxel and curcumin liposomes based on cellular morphology changes. AAPS Open 10, 1 (2024).

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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DSPE-PEG2000-GE11

Voir tous les produits spécifiques à Isoform EGFR