Dag1 - dystroglycan 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114489

Summary

Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; cellular response to cholesterol; and nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Apr 2022]

Dag1 Products (1)

mRNA Protein Name
NM_053697.1 NP_446149.1 dystroglycan precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables laminin binding IDA
IDA: Inferred from direct assay
8996823 RGD
enables laminin-1 binding IDA
IDA: Inferred from direct assay
9153251 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15247274 RGD
Biological Process GO Annotation Evidence Références Source
involved in Schwann cell differentiation IEP
IEP: Inferred from expression pattern
11869039 RGD
involved in angiogenesis involved in wound healing IEP
IEP: Inferred from expression pattern
21192954 RGD
involved in axon regeneration IEP
IEP: Inferred from expression pattern
16228655 RGD
involved in calcium-dependent cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
12177244 RGD
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
22613990 RGD
involved in cellular response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
18556591 RGD
involved in nerve development IEP
IEP: Inferred from expression pattern
16228655 RGD
involved in positive regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
9153251 RGD
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
17395644 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17395644 RGD
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
18556591 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
8906620 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
11416038 RGD
involved in skeletal muscle tissue regeneration IEP
IEP: Inferred from expression pattern
12086334 RGD
Cellular Component GO Annotation Evidence Références Source
located in adherens junction IDA
IDA: Inferred from direct assay
9117347 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11416038 RGD
located in costamere IDA
IDA: Inferred from direct assay
10531619 RGD
part of dystrophin-associated glycoprotein complex IDA
IDA: Inferred from direct assay
15247274 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9153251 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
9117347 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9446825 RGD
located in nuclear periphery IDA
IDA: Inferred from direct assay
21668890 RGD
located in plasma membrane raft IDA
IDA: Inferred from direct assay
22613990 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
9446825 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
10531619 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dystroglycan

  • alpha-dystroglycan

  • beta-dystroglycan

  • dystroglycan 1 (dystrophin-associated glycoprotein 1)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03519 DAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18922 Dag1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25412 Dag1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P992223 Anti-DAG1/Dystroglycan Antibody (DAG-6F4) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dag1 NCBI NCBI:1605