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Cat. No.: HY-P992223

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Anti-DAG1/Dystroglycan Antibody (DAG-6F4)

Anti-DAG1/Dystroglycan Antibody (DAG-6F4) is a human monoclonal antibody against DAG1/Dystroglycan. Anti-DAG1/Dystroglycan Antibody (DAG-6F4) can bind specifically to the α and β subunits of the dystroglycan protein complex. Anti-DAG1/Dystroglycan Antibody (DAG-6F4) is applicable to research related to muscular dystrophy.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anti-DAG1/Dystroglycan Antibody (DAG-6F4) Chemical Structure

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Anti-DAG1/Dystroglycan Antibody (DAG-6F4) Product Recommendations:

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Species Reactivity

Human

IC₅₀ & Target

^[1]

DAG1

In Vitro

Anti-DAG1/Dystroglycan Antibody (DAG-6F4) (35 μg/mL; 1 h) specifically binds to a unique 7-amino acid epitope (PNQRPEL, amino acids 493-499) located in the C-terminal region of human α-dystroglycan^[1].
Anti-DAG1/Dystroglycan Antibody (DAG-6F4) (35 μg/mL, 1:50 dilution; 1 h, overnight at 4 °C) labels the sarcolemma of normal human skeletal muscle, and its staining intensity is significantly reduced in Duchenne muscular dystrophy muscle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

1605 [NCBI]

Accession

Q14118

Target

DAG1/Dystroglycan

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Humphrey EL, et al;. A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core protein in some, but not all, dystroglycanopathy patients. Neuromuscul Disord. 2015 Jan;25(1):32-42. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Anti-DAG1/Dystroglycan Antibody (DAG-6F4)

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Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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Anti-DAG1/Dystroglycan Antibody (DAG-6F4)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Biological Activity

Description

Species Reactivity

IC50 & Target

In Vitro

Gene ID

Accession

Target

Conjugated

Reconsititution

Format

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs