Six2 - sine oculis-related homeobox 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20472

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; kidney development; and positive regulation of chondrocyte proliferation. Acts upstream of or within several processes, including animal organ development; condensed mesenchymal cell proliferation; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SIX2 (SIX homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Six2 Products (1)

mRNA Protein Name
NM_011380.2 NP_035510.1 homeobox protein SIX2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15327782 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15327782 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15327782 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11734542 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17785448 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8814301 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
22902740 MGI
Biological Process GO Annotation Evidence Références Source
involved in anterior/posterior axis specification IDA
IDA: Inferred from direct assay
18321982 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
20515681 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
20515681 MGI
acts upstream of or within condensed mesenchymal cell proliferation IGI
IGI: Inferred from genetic interaction
26116661 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
20515681 MGI
involved in embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19660448 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
15634706 MGI
acts upstream of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17036046 MGI
involved in kidney development IMP
IMP: Inferred from mutant phenotype
17036046 MGI
involved in mesenchymal cell differentiation involved in kidney development IMP
IMP: Inferred from mutant phenotype
17036046 MGI
involved in mesenchymal stem cell maintenance involved in nephron morphogenesis IDA
IDA: Inferred from direct assay
22902740 MGI
involved in mesenchymal stem cell maintenance involved in nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
18682239 MGI
involved in mesenchymal stem cell proliferation IMP
IMP: Inferred from mutant phenotype
21350016 MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
IEP: Inferred from expression pattern
10322633 MGI
involved in mesodermal cell fate specification IDA
IDA: Inferred from direct assay
17785448 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
17036046 MGI
acts upstream of or within middle ear morphogenesis IGI
IGI: Inferred from genetic interaction
15634706 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17036046 MGI
involved in nephron development IMP
IMP: Inferred from mutant phenotype
18682239 MGI
involved in nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
17036046 MGI
involved in positive regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
20515681 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15327782 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
16024294 MGI
involved in regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17036046 MGI
involved in regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
20515681 MGI
involved in regulation of ossification IMP
IMP: Inferred from mutant phenotype
20515681 MGI
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
8814301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein SIX2

  • sine oculis homeobox homolog 2

  • sine oculis-related homeobox 2 homolog

Six2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Six2 Q62232 Eya1 Mus musculus P97767
Pull Down
11734542
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12959 SIX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19955 Six2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26457 Six2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Six2 NCBI NCBI:10736