Nr2c1 - nuclear receptor subfamily 2, group C, member 1 Gene

Also Known as TR2; 80.3; Eenr; Tr2-11; 4831444H07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22025

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of retinoic acid receptor signaling pathway. Located in PML body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; jaw; and sensory organ. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr2c1 Products (1)

mRNA Protein Name
NM_011629.3 NP_035759.3 nuclear receptor subfamily 2 group C member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA binding IDA
IDA: Inferred from direct assay
9071982 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9369481 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9369481 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
11463856 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9774688 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
9369481 MGI
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8858600 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8858600 MGI
involved in positive regulation of retinoic acid receptor signaling pathway IDA
IDA: Inferred from direct assay
16130175 MGI
Cellular Component GO Annotation Evidence Références Source
located in PML body IDA
IDA: Inferred from direct assay
18682553 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9795341 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 2 group C member 1

  • 80-3 cNDA

  • early embryonic nuclear receptor

  • mTR2

  • nuclear receptor subfamily 2, group H, member 1

  • orphan nuclear receptor TR2

  • orphan receptor, TR2-11

  • testicular receptor 2

Nr2c1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Nr2c1 Q505F1 Pml Mus musculus Q8BSJ6
Anti Tag CoIP
18682553
Intra
Nr2c1 Q505F1 Pml Mus musculus Q8BSJ6
Anti Bait CoIP
18682553
Intra
Nr2c1 Q505F1 Nrip1 Mus musculus Q8CBD1
Anti Tag CoIP
17187077
Intra
Nr2c1 Q505F1 Nrip1 Mus musculus Q8CBD1
Y2H
17187077
Intra
Nr2c1 Q505F1 Nrip1 Mus musculus Q8CBD1
Y2H
18682553
Intra
Nr2c1 Q505F1 Kat2b Mus musculus Q9JHD1
Interaction Detect
17187077
Intra
Nr2c1 Q505F1 Kat2b Mus musculus Q9JHD1
Y2H
17187077
Intra
Nr2c1 Q505F1 Kat2b Mus musculus Q9JHD1
Y2H
18682553
Intra
Nr2c1 Q505F1 Pias1 Mus musculus O88907
Y2H
17187077
Intra
Nr2c1 Q505F1 Pias1 Mus musculus O88907
Pull Down
17187077
Intra
Nr2c1 Q505F1 Pias1 Mus musculus O88907
Anti Bait CoIP
17187077
Intra
Nr2c1 Q505F1 Pml Mus musculus Q60953
Anti Bait CoIP
17187077
Intra
Nr2c1 Q505F1 Sumo1 Mus musculus P63166
Anti Bait CoIP
17187077
Intra
Nr2c1 Q505F1 Sumo1 Mus musculus P63166
Anti Bait CoIP
18682553
Intra
Nr2c1 Q505F1 Sumo1 Mus musculus P63166
Interaction Detect
17187077
Intra
Nr2c1 Q505F1 Ube2i Mus musculus P63280
Pull Down
17187077
Intra
Nr2c1 Q505F1 Ube2i Mus musculus P63280
Y2H
17187077
Intra
Nr2c1 Q505F1 Ube2i Mus musculus P63280
Anti Bait CoIP
17187077
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-105353 CEB-1604 Antagonist / Unkown
HY-RS09536 NR2C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22686 Nr2c1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29200 Nr2c1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr2c1 NCBI NCBI:7181