Pml - promyelocytic leukemia Gene

Also Known as Trim19; 1200009E24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18854

Summary

Enables SMAD binding activity. Involved in several processes, including defense response to Other organism; regulation of gene expression; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in PML body; cytosol; and nuclear matrix. Is extrinsic component of endoplasmic reticulum membrane. Colocalizes with heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin Cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2022]

Pml Products (3)

mRNA Protein Name
NM_001311088.1 NP_001298017.1 protein PML isoform 3
NM_008884.5 NP_032910.3 protein PML isoform 1
NM_178087.4 NP_835188.2 protein PML isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables SMAD binding IDA
IDA: Inferred from direct assay
15356634 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12529400 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: Inferred from mutant phenotype
15626733 MGI
acts upstream of or within PML body organization IDA
IDA: Inferred from direct assay
12529400 MGI
acts upstream of or within SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
15356634 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
9806545 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
19261859 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
19261859 MGI
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
9798653 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
22274616 MGI
involved in endoplasmic reticulum calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
21030605 MGI
involved in entrainment of circadian clock by photoperiod IDA
IDA: Inferred from direct assay
22274616 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
9806545 MGI
involved in fibroblast migration IMP
IMP: Inferred from mutant phenotype
23555679 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
14992722 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
9806545 MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15626733 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
21030605 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
21030605 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
9488655 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
16915281 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9488655 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
24407287 MGI
involved in negative regulation of interleukin-1 production IMP
IMP: Inferred from mutant phenotype
24407287 MGI
involved in oncogene-induced cell senescence IMP
IMP: Inferred from mutant phenotype
10910364 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
10684855 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10684855 MGI
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
23555679 MGI
involved in positive regulation of peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
10910364 MGI
involved in positive regulation of signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
10910364 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
15356634 MGI
acts upstream of or within protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
15356634 MGI
involved in regulation of calcium ion transport into cytosol IMP
IMP: Inferred from mutant phenotype
21030605 MGI
involved in regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
23555679 MGI
involved in regulation of circadian rhythm IDA
IDA: Inferred from direct assay
22274616 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
15626733 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
9806545 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
16915281 MGI
acts upstream of or within retinoic acid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9488655 MGI
involved in suppression of viral release by host IDA
IDA: Inferred from direct assay
18248090 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15356634 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in PML body IDA
IDA: Inferred from direct assay
16461359 MGI
located in PML body IMP
IMP: Inferred from mutant phenotype
10779416 MGI
located in cytosol IDA
IDA: Inferred from direct assay
21030605 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
15252119 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10716735 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein PML

  • probable transcription factor PML

Pml Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Pml Q8BSJ6 Nr2c1 Mus musculus Q505F1
Anti Bait CoIP
18682553
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-N10633 LSTc 99.64% Unkown
HY-127130 Spicamycin / Unkown
HY-175354 PROTAC BET Degrader-13 Degrader / Unkown
HY-RS10765 PML Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18592 Pml Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25077 Pml Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pml NCBI NCBI:5371