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Cat. No.: HY-175354

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PROTAC BET Degrader-13

PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC₅₀ of 1.4 μM.
(Pink: BET ligand (HY-13030); Blue: TRIM21 ligand (HY-W1125585); Black: linker).

For research use only. We do not sell to patients.

Formula: C₄₇H₅₄ClN₉O₆S
Molecular Weight:908.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PROTAC BET Degrader-13 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC₅₀ of 1.4 μM^[1]. (Pink: BET ligand (HY-13030); Blue: TRIM21 ligand (HY-W1125585); Black: linker).

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

Chemical Information

Molecular Weight 908.51
Formula C₄₇H₅₄ClN₉O₆S
SMILES

O=C(C[C@H]1N=C(C2=C(N3C(C)=NN=C13)SC=C2C)C4=CC=C(C=C4)Cl)NCCOCCOCCOCc5cc(N6C(C7=CC=CC=C7N=C6CN8CCNC[C@@H]8C)=O)c(OCC)cc5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Scemama de Gialluly MA, et al. Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates. Nat Commun. 2025 Jul 16;16(1):6548. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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References

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PROTAC BET Degrader-13

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BET Degrader-13 Related Classifications

HY-175354 Related Classifications