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Cat. No.: HY-W1125585

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PRLX-93936 analog 1

PRLX-93936 analog 1 is a TRIM21-targeting cytotoxin. PRLX-93936 analog 1 binds to the TRIM21 PRYSPRY domain, inducing TRIM21-mediated ubiquitination and degradation of nucleoporin proteins. PRLX-93936 analog 1 impairs nuclear trafficking, triggering cell death. PRLX-93936 analog 1 exhibits TRIM21-dependent cytotoxicity, suppressible by TRIM21 ligand HGC1g. PRLX-93936 analog 1 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₆N₄O₂
Molecular Weight:378.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PRLX-93936 analog 1 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

TRIM21

In Vitro

PRLX-93936 analog 1 (Compound 1) (0.4-50 μM; 3 h) directly competes with IgG for binding to the PRYSPRY domain of endogenous TRIM21 from OCI-AML-3 cell lysates in a dose-dependent manner^[1].
PRLX-93936 analog 1 (0-1000 nM; 24 h) potently induces TRIM21-dependent cell death in OCI-AML-3 cells with an EC₅₀ of 3 nM^[1].
PRLX-93936 analog 1 (0-1000 nM; 24 h) potently induces TRIM21-dependent cell death in Jurkat cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

OCI-AML-3
Concentration:

0 nM, 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1000 nM
Incubation Time:

24 h
Result:

Induced potent TRIM21-dependent cell death with an EC₅₀ of 3 nM.
Rendered TRIM21 knockout OCI-AML-3 cells fully resistant at concentrations up to 2 μM.

Cell Viability Assay^[1]

Cell Line:

Jurkat
Concentration:

0 nM, 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1000 nM
Incubation Time:

24 h
Result:

Induced potent TRIM21-dependent cell death.
Rendered TRIM21 knockout Jurkat cells fully resistant at concentrations up to 2 μM.

Chemical Information

Molecular Weight 378.47
Formula C₂₂H₂₆N₄O₂
SMILES

O=C1N(c2c(OCC)cccc2)C(CN3CCNC[C@@H]3C)=NC4=CC=CC=C14
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Scemama de Gialluly MA, et al. Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates. Nature communications. 2025 Jul 16;16(1):6548. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Minimum order quantity

100 mg

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