CYP3A5 - Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Gene

Also Known as CYP; RL33; cDEX; Cyp3a1; Cyp3a3; CYP3A23; Cyp3a23/3a1; AABR07035343.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25642

Summary

Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including oxidative demethylation; response to cadmium ion; and response to dexamethasone. Located in endoplasmic reticulum membrane. Biomarker of cholestasis and mental depression. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (Cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]

CYP3A5 Products (2)

mRNA Protein Name
NM_013105.2 NP_037237.2 cytochrome P450 3A1
NM_013105.2 NP_037237.2 cytochrome P450 3A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables demethylase activity IDA
IDA: Inferred from direct assay
12971802 RGD
enables testosterone 6-beta-hydroxylase activity IDA
IDA: Inferred from direct assay
9989933 RGD
Biological Process GO Annotation Evidence Références Source
involved in oxidative demethylation IDA
IDA: Inferred from direct assay
12971802 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
14595535 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
27856527 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
25011215 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
15349958 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
16039771 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16380645 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17484520 RGD
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
12971802 RGD
Cellular Component GO Annotation Evidence Références Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
8841512 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 3A1

  • CYPIIIA1

  • Cytochrome P450, subfamily IIIA, polypeptide 3

  • P450 IIIA

  • P450-PCN1

  • cytochrome P-450

  • cytochrome P-450PCN (PNCN inducible)

  • cytochrome P450 3A1-like

  • cytochrome P450, family 3, subfamily a, polypeptide 1

  • cytochrome P450, subfamily 3A, polypep

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-13600 Clobetasol propionate Inhibitor 99.87% Yes
HY-13600R Clobetasol propionate (Standard) Inhibitor 99.68% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-109173 Filapixant 99.10% Phase 2
HY-14901 Telapristone Antagonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-18642 CYP3cide Inhibitor 99.92% Unkown
HY-124265 4β-Hydroxycholesterol 99.96% Unkown
HY-117605 N-Desmethyl Sildenafil Inhibitor 99.60% Unkown
HY-113031 16a-Hydroxydehydroisoandrosterone 98.54% Unkown
HY-135810 Cletoquine Inhibitor / Unkown
HY-135810A Cletoquine oxalate Inhibitor 99.63% Unkown
HY-145000 N-Desalkyludenafil 99.16% Unkown
HY-18642A (R)-CYP3cide Control 99.46% Unkown
HY-135810S Cletoquine-d4 Inhibitor / Unkown
HY-135810S1 Cletoquine-d4-1 Inhibitor / Unkown
HY-13600S1 Clobetasol propionate-d5 Inhibitor / Unkown
HY-N17811 Vincristine metabolite-1 / Unkown
HY-RS03473 CYP3A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W744187 Clobetasol 17-Propionate-d5 / Unkown
HY-W777442 Cletoquine-d4 Oxalate Inhibitor / Unkown
HY-W740175 6b-Hydroxy triamcinolone acetonide Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYP3A5 NCBI NCBI:1577