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Cat. No.: HY-N17811

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Vincristine metabolite-1

Vincristine metabolite-1 (Compound M1) is the major metabolite of Vincristine (HY-N0488A) by CYP3A4 and CYP3A5.

For research use only. We do not sell to patients.

CAS No.: 910580-56-2
Formula: C₄₅H₅₄N₄O₁₀
Molecular Weight:810.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Vincristine metabolite-1 Chemical Structure

CAS No.: 910580-56-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Vincristine metabolite-1 (Compound M1) is the major metabolite of Vincristine (HY-N0488A) by CYP3A4 and CYP3A5^[1].

Chemical Information

CAS No. 910580-56-2
Molecular Weight 810.93
Formula C₄₅H₅₄N₄O₁₀
SMILES

CC[C@@]12[C@@]3([H])[C@]4(CCN3CC=C2)[C@](N(C5=CC(OC)=C([C@@]6(C7=C(CCNC[C@@H](C6)CC(CC)=O)C8=CC=CC=C8N7)C(OC)=O)C=C54)C=O)([H])[C@](O)([C@@H]1OC(C)=O)C(OC)=O
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dennison JB, et al. Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes. J Pharmacol Exp Ther. 2008;327(1):248-257. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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