BZW2 - basic leucine zipper and W2 domains 2 Gene

Also Known as 5MP1; MST017; HSPC028; MSTP017

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28969

About BZW2

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:16,646,181-16,706,517 (from NCBI)

This gene has 13 transcripts (splice variants), 181 orthologues and 1 paralogue. Broad expression in heart (RPKM 82.0), placenta (RPKM 43.3) and 22 other tissues.

Summary

Enables Cadherin binding activity. Predicted to be involved in cell differentiation and nervous system development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BZW2 Products (5)

mRNA Protein Name
NM_001159767.2 NP_001153239.1 eIF5-mimic protein 1 isoform 1
NM_001362717.2 NP_001349646.1 eIF5-mimic protein 1 isoform 1
NM_001362718.2 NP_001349647.1 eIF5-mimic protein 1 isoform 2
NM_001362719.2 NP_001349648.1 eIF5-mimic protein 1 isoform 2
NM_014038.3 NP_054757.1 eIF5-mimic protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21745818 GOA
Biological Process GO Annotation Evidence Références Source
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
21745818 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21745818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BZW2 Protein Structure

W2

W2: eIF4-gamma/eIF5/eIF2-epsilon (338 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

eIF5-mimic protein 1

  • basic leucine zipper and W2 domain-containing protein 2

BZW2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
BZW2 Q9Y6E2 EIF2S2 Homo sapiens P20042
ITC
25147208
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BZW2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P700393 BZW2 Protein, Human (GST) Q9Y6E2-1 (M1-N419) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS01690 BZW2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20255 Bzw2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26763 Bzw2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BZW2 VGNC VGNC:26613
Felis catus BZW2 VGNC VGNC:60216
Macaca mulatta BZW2 VGNC VGNC:70344
Rattus norvegicus BZW2 RGD RGD:621507
Mus musculus BZW2 MGD MGI:1914162
Canis familiaris BZW2 VGNC VGNC:38572
Others BZW2 NCBI