NEXMIF - neurite extension and migration factor Gene

Also Known as XPN; MRX98; KIDLIA; XLID98; KIAA2022

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340533

About NEXMIF

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:74,732,856-74,925,452 (from NCBI)

This gene has 3 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 2.3), adrenal (RPKM 0.6) and 12 other tissues.

Summary

An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked cognitive disability.[provided by RefSeq, Mar 2009]

NEXMIF Products (1)

mRNA	Protein	Name
NM_001008537.3	NP_001008537.1	neurite extension and migration factor

Protein Preferred Names	Protein Names
neurite extension and migration factor	XLMR protein related to neurite extension

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 98	X-Linked Intellectual Disability, Cantagrel Type XLID98 Mental Retardation, X-Linked 98 Mrx98 Mental Retardation, X-Linked, Type 98
Continuous Spike-Wave During Slow Sleep Syndrome	Csws Cswss Syndrome Continuous Spikes And Waves During Sleep Continuous Spikes And Waves During Slow-Wave Sleep Epileptic Encephalopathy With Continuous Spike-And-Wave During Slow Sleep Continuous Spike And Waves During Slow Sleep Continuous Spike And Waves During Slow-Wave Sleep Syndrome
Epilepsy, Focal, With Speech Disorder And With Or Without Impaired Intellectual Development	Continuous Spike And Waves During Slow-Wave Sleep Syndrome FESD Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation Aphasia, Acquired, With Epilepsy Landau-Kleffner Syndrome Acquired Aphasia With Epilepsy Adresd Bects Benign Epilepsy Of Childhood With Centrotemporal Spikes Csws Cswss Lks Resdad Epilepsy, Focal, With Speech Disorder With/Without Mental Retardation Rolandic Epilepsy, Mental Retardation, And Speech Dyspraxia, Autosomal Dominant Benign Rolandic Epilepsy Aphasia
Epilepsy With Myoclonic-Atonic Seizures	Myoclonic Astatic Epilepsy Doose Syndrome Epilepsy With Myoclonic-Astatic Seizures Epilepsy With Myoclono-Astatic Crisis Myoclonic-Astatic Epilepsy Emas Mae Myoclonic Atonic Epilepsy Myoclonic-Astatic Epilepsy In Early Childhood
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Non-Syndromic X-Linked Intellectual Disability 98	Mrx98 X-Linked Mental Retardation 98
Non-Syndromic X-Linked Intellectual Disability 91	Mrx91
Xia-Gibbs Syndrome	Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome XIGIS Mrd25 Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome Mental Retardation, Autosomal Dominant 25, Formerly Mrd25, Formerly Autosomal Dominant Mental Retardation 25 Autosomal Dominant Intellectual Disability 25 Xgs
Non-Syndromic X-Linked Intellectual Disability 58	Mrx58
Developmental And Epileptic Encephalopathy 26	DEE26 Epileptic Encephalopathy, Early Infantile, 26 Eiee26 Early Infantile Epileptic Encephalopathy 26 Developmental And Epileptic Encephalopathy, 26 Encephalopathy, Epileptic, Early Infantile, Type 26
Tonne-Kalscheuer Syndrome	TOKAS Mrx61 Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia Mental Retardation, X-Linked 61 X-Linked Mental Retardation 61
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Cardiomyopathy, Dilated, 1hh	Dilated Cardiomyopathy 1hh CMD1HH Cardiomyopathy, Dilated 1hh Cardiomyopathy, Dilated, Type 1hh
Borjeson-Forssman-Lehmann Syndrome	BFLS Borj Borjeson Syndrome Mrxsbfl Intellectual Deficiency-Epilepsy-Endocrine Disorders Syndrome Intellectual Disability-Epilepsy-Endocrine Disorders Syndrome Mental Retardation, X-Linked, Syndromic, Borjeson-Forssman-Lehmann Type Mental Retardation, Epilepsy, And Endocrine Disorders Mental Retardation, Epilepsy, And Endocrine Disorder Syndromic X-Linked Mental Retardation Borjeson-Forssman-Lehmann Type Mental Deficiency, Epilepsy And Endocrine Disorders Boerjeson-Forssman-Lehmann Syndrome Borjeson-Forssman Syndrome Mental Deficiency-Epilepsy- Endocrine Disorders
Photosensitive Epilepsy	Pse Photogenic Epilepsy Photoparoxysmal Response Reflex Epilepsy, Photosensitive Photoparoxysmal Response 1
Partington Syndrome	X-Linked Reticulate Pigmentary Disorder PRTS Partington X-Linked Mental Retardation Syndrome Mrxs1 Mrx36 Intellectual Developmental Disorder, X-Linked, Syndromic 1 Partington Disease Pdr Partington-Mulley Syndrome Russell-Silver Syndrome, X-Linked Mental Retardation, X-Linked, Syndromic 1 Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures Mental Retardation, X-Linked 36 X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations X-Linked Russell-Silver Syndrome Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome Intellectual Disability, X-Linked, Syndromic 1 Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures Partington X-Linked Intellectual Disability Syndrome X-Linked Intellectual Deficit-Dystonia-Dysarthria X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures Familial Cutaneous Amyloidosis X-Linked Cutaneous Amyloidosis Xlpdr X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome Pigmentary Disorder, Reticulate, With Systemic Manifestations
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09231	NEXMIF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NEXMIF	VGNC	VGNC:63786
Canis familiaris	NEXMIF	VGNC	VGNC:43759
Macaca mulatta	NEXMIF	VGNC	VGNC:75274
Rattus norvegicus	NEXMIF	RGD	RGD:1561931
Bos taurus	NEXMIF	VGNC	VGNC:32024
Mus musculus	NEXMIF	MGD	MGI:2148050
Others	NEXMIF	NCBI