RHOH - ras homolog family member H Gene

Also Known as TTF; ARHH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 399

About RHOH

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,191,080-40,246,967 (from NCBI)

This gene has 17 transcripts (splice variants), 184 orthologues, 22 paralogues and is associated with 53 phenotypes. Biased expression in lymph node (RPKM 20.2), bone marrow (RPKM 10.8) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing Enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

RHOH Products (12)

mRNA	Protein	Name
NM_001278359.2	NP_001265288.1	rho-related GTP-binding protein RhoH precursor
NM_001278360.2	NP_001265289.1	rho-related GTP-binding protein RhoH precursor
NM_001278361.2	NP_001265290.1	rho-related GTP-binding protein RhoH precursor
NM_001278362.2	NP_001265291.1	rho-related GTP-binding protein RhoH precursor
NM_001278363.2	NP_001265292.1	rho-related GTP-binding protein RhoH precursor
NM_001278364.2	NP_001265293.1	rho-related GTP-binding protein RhoH precursor
NM_001278365.2	NP_001265294.1	rho-related GTP-binding protein RhoH precursor
NM_001278366.2	NP_001265295.1	rho-related GTP-binding protein RhoH precursor
NM_001278367.2	NP_001265296.1	rho-related GTP-binding protein RhoH precursor
NM_001278368.2	NP_001265297.1	rho-related GTP-binding protein RhoH precursor
NM_001278369.2	NP_001265298.1	rho-related GTP-binding protein RhoH precursor
NM_004310.5	NP_004301.1	rho-related GTP-binding protein RhoH precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables GTP binding	IDA IDA: Inferred from direct assay	11809807	GOA
enables kinase inhibitor activity	IDA IDA: Inferred from direct assay	11809807	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11809807	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11809807	GOA
involved in positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	22850876	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11809807	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOH Protein Structure

Ras

0
100
191 a.a.

Protein Preferred Names	Protein Names
rho-related GTP-binding protein RhoH	GTP-binding protein TTF

RHOH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RHOH	Q15669	IQUB	Homo sapiens	Q8NA54	Validated Y2H	32296183
Intra	RHOH	Q15669	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	RHOH	Q15669	SORL1	Homo sapiens	Q92673	Validated Y2H	32296183
Intra	RHOH	Q15669	PLEKHA7	Homo sapiens	Q6IQ23-2	Validated Y2H	32296183
Intra	RHOH	Q15669	XPNPEP1	Homo sapiens	Q9NQW7-3	Validated Y2H	32296183
Intra	RHOH	Q15669	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	RHOH	Q15669	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	RHOH	Q15669	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
Intra	RHOH	Q15669	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epidermodysplasia Verruciformis 4	Epidermodysplasia Verruciformis, Susceptibility To, 4 EV4 T-Cell Immunodeficiency With Epidermodysplasia Verruciformis T-Cell Immunodeficiency Due To Rhoh Deficiency {Epidermodysplasia Verruciformis, Susceptibility To, 4}
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Pityriasis Versicolor	Tinea Versicolor Infection By Pityrosporum Furfur
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Superficial Mycosis	Piedra Steroid-Modified Tinea Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS11954	RHOH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20334	Rhoh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26842	Rhoh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RHOH	VGNC	VGNC:68162
Canis familiaris	RHOH	VGNC	VGNC:45561
Macaca mulatta	RHOH	VGNC	VGNC:76884
Mus musculus	RHOH	MGD	MGI:1921984
Bos taurus	RHOH	VGNC	VGNC:33950
Rattus norvegicus	RHOH	RGD	RGD:1307623
Others	RHOH	NCBI