MEIS3 - Meis homeobox 3 Gene

Also Known as MRG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56917

About MEIS3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,403,124-47,422,233 (from NCBI)

This gene has 14 transcripts (splice variants), 192 orthologues and 12 paralogues. Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues.

Summary

This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]

MEIS3 Products (4)

mRNA Protein Name
NM_001009813.3 NP_001009813.1 homeobox protein Meis3 isoform 2
NM_001301059.2 NP_001287988.1 homeobox protein Meis3 isoform 3
NM_001346148.2 NP_001333077.1 homeobox protein Meis3 isoform 4
NM_020160.3 NP_064545.1 homeobox protein Meis3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17178831 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEIS3 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (280 - 319)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

homeobox protein Meis3

  • Meis1, myeloid ecotropic viral integration site 1 homolog 3

Related Diseases

Diseases Alias
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08327 MEIS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MEIS3 RGD RGD:1308532
Mus musculus MEIS3 MGD MGI:108519
Bos taurus MEIS3 VGNC VGNC:52205
Canis familiaris MEIS3 VGNC VGNC:53737
Others MEIS3 NCBI