SNX16 - sorting nexin 16 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64089

About SNX16

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,799,583-81,842,185 (from NCBI)

This gene has 11 transcripts (splice variants), 237 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 6.1), esophagus (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, Cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]

SNX16 Products (4)

mRNA Protein Name
NM_001348189.2 NP_001335118.1 sorting nexin-16 isoform c
NM_022133.4 NP_071416.2 sorting nexin-16 isoform a
NM_152836.3 NP_690049.1 sorting nexin-16 isoform a
NM_152837.3 NP_690050.1 sorting nexin-16 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12813048 GOA
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
12813048 GOA
Biological Process GO Annotation Evidence Références Source
involved in early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
12813048 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
12813048 GOA
involved in protein targeting to lysosome IMP
IMP: Inferred from mutant phenotype
12813048 GOA
Cellular Component GO Annotation Evidence Références Source
located in early endosome IDA
IDA: Inferred from direct assay
12813048 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
12813048 GOA
located in late endosome IDA
IDA: Inferred from direct assay
12813048 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX16 Protein Structure

PX

PX: PX domain (118 - 211)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

sorting nexin-16

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 15

  • SCA15

  • Spinocerebellar Ataxia Type 15

  • Spinocerebellar Ataxia Type 16

  • Sca16

  • Spinocerebellar Ataxia Type 15/16

  • Spinocerebellar Ataxia 16, Formerly

  • Sca16, Formerly

  • Spinocerebellar Ataxia 16

  • Sca15/16

  • Ataxia, Spinocerebellar, Type 15
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13529 SNX16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SNX16 MGD MGI:1921968
Rattus norvegicus SNX16 RGD RGD:620295
Bos taurus SNX16 VGNC VGNC:35096
Canis familiaris SNX16 VGNC VGNC:46625
Macaca mulatta SNX16 VGNC VGNC:77710
Felis catus SNX16 VGNC VGNC:65546
Others SNX16 NCBI