MINDY3 - MINDY lysine 48 deubiquitinase 3 Gene

Also Known as CARP; DERP5; my042; MST126; FAM188A; MSTP126; C10orf97

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80013

About MINDY3

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,778,174-15,860,507 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 5.8), adrenal (RPKM 4.8) and 25 other tissues.

Summary

The protein encoded by this gene contains a caspase-associated recruitment domain and may function in Apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric Cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

MINDY3 Products (2)

mRNA Protein Name
NM_001318330.2 NP_001305259.1 ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform b precursor
NM_024948.4 NP_079224.1 ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
27292798 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
27292798 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21499297 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MINDY3 Protein Structure

DUF4205

DUF4205: Domain of unknown function (DUF4205) (28 - 300)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase MINDY-3

  • CARD-containing protein

MINDY3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MINDY3 Q9H8M7 COPS5 Homo sapiens Q92905
Confocal
21499297
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pollen Allergy

  • Hay Fever
Fish Allergy

  • Allergy To Fish
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08453 MINDY3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MINDY3 VGNC VGNC:74811
Mus musculus MINDY3 MGD MGI:1914210
Felis catus MINDY3 VGNC VGNC:63512
Bos taurus MINDY3 VGNC VGNC:31478
Rattus norvegicus MINDY3 RGD RGD:1309605
Canis familiaris MINDY3 VGNC VGNC:49794
Others MINDY3 NCBI