MYO19 - myosin XIX Gene

Also Known as MYOHD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80179

About MYO19

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,495,636-36,544,815 (from NCBI)

This gene has 27 transcripts (splice variants), 1 gene allele, 195 orthologues and 43 paralogues. Ubiquitous expression in skin (RPKM 10.8), esophagus (RPKM 7.0) and 25 other tissues.

Summary

Enables actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

MYO19 Products (3)

mRNA Protein Name
NM_001033580.3 NP_001028752.1 unconventional myosin-XIX isoform 3
NM_001163735.2 NP_001157207.1 unconventional myosin-XIX isoform 2
NM_025109.6 NP_079385.2 unconventional myosin-XIX isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
23568824 GOA
enables actin binding IDA
IDA: Inferred from direct assay
23568824 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within mitochondrion migration along actin filament IDA
IDA: Inferred from direct assay
19932026 GOA
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
25447992 GOA
involved in regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
25447992 GOA
Cellular Component GO Annotation Evidence Références Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
27126804 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
23568824 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO19 Protein Structure

Myosin_head

Myosin_head: Myosin head (motor domain) (38 - 674)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 970 a.a.
Protein Preferred Names Protein Names

unconventional myosin-XIX

  • myosin head domain containing 1

MYO19 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83537 MYO19 Antibody (YA3282) WB Human, Mouse
HY-P83537A MYO19 Antibody (YA3282)(PBS only) WB Human, Mouse

Related Diseases

Diseases Alias
Glycosylphosphatidylinositol Biosynthesis Defect 11

  • GPIBD11

  • Hyperphosphatasia With Mental Retardation Syndrome 5

  • Hpmrs5

  • Hyperphosphatasia With Mental Retardation Syndrome, Type 5
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08936 MYO19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29508 Myo19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MYO19 RGD RGD:1559961
Macaca mulatta MYO19 VGNC VGNC:75026
Mus musculus MYO19 MGD MGI:1913446
Canis familiaris MYO19 VGNC VGNC:43559
Felis catus MYO19 VGNC VGNC:63686
Bos taurus MYO19 VGNC VGNC:31815
Others MYO19 NCBI