ALKBH7 - alkB homolog 7 Gene

Also Known as ABH7; SPATA11; UNQ6002

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84266

About ALKBH7

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,372,794-6,375,250 (from NCBI)

This gene has 3 transcripts (splice variants) and 192 orthologues. Broad expression in testis (RPKM 38.0), kidney (RPKM 14.9) and 24 other tissues.

Summary

Predicted to enable dioxygenase activity and metal ion binding activity. Involved in cellular response to DNA damage stimulus and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH7 Products (1)

mRNA Protein Name
NM_032306.4 NP_115682.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
23666923 GOA
involved in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
23666923 GOA
Cellular Component GO Annotation Evidence Références Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
23666923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH7 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (75 - 199)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

  • alkB, alkylation repair homolog 7

ALKBH7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
ALKBH7 Q9BT30 KIAA1217 Homo sapiens Q5T5P2-6
Y2H Array
32296183
Intra
ALKBH7 Q9BT30 KIAA1217 Homo sapiens Q5T5P2-6
Y2H Prey Pooling
32296183
Intra
ALKBH7 Q9BT30 CIMIP1 Homo sapiens Q9H1P6
Y2H Prey Pooling
32296183
Intra
ALKBH7 Q9BT30 CIMIP1 Homo sapiens Q9H1P6
Validated Y2H
32296183
Intra
ALKBH7 Q9BT30 CIMIP1 Homo sapiens Q9H1P6
Y2H Array
32296183
Intra
ALKBH7 Q9BT30 CENPN Homo sapiens Q96H22-3
Y2H Array
32296183
Intra
ALKBH7 Q9BT30 CENPN Homo sapiens Q96H22-3
Y2H Prey Pooling
32296183
Intra
ALKBH7 Q9BT30 B9D2 Homo sapiens Q9BPU9
Y2H Array
32296183
Intra
ALKBH7 Q9BT30 B9D2 Homo sapiens Q9BPU9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00608 ALKBH7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ALKBH7 VGNC VGNC:69663
Canis familiaris ALKBH7 VGNC VGNC:37807
Bos taurus ALKBH7 VGNC VGNC:25838
Felis catus ALKBH7 VGNC VGNC:59753
Rattus norvegicus ALKBH7 RGD RGD:1598126
Mus musculus ALKBH7 MGD MGI:1913650
Others ALKBH7 NCBI