GAS7 - growth arrest specific 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8522

About GAS7

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,910,606-10,198,606 (from NCBI)

This gene has 19 transcripts (splice variants), 273 orthologues, 5 paralogues and is associated with 74 phenotypes. Broad expression in brain (RPKM 53.9), skin (RPKM 13.3) and 17 other tissues.

Summary

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GAS7 Products (4)

mRNA Protein Name
NM_001130831.2 NP_001124303.1 growth arrest-specific protein 7 isoform d
NM_003644.3 NP_003635.2 growth arrest-specific protein 7 isoform a
NM_201432.2 NP_958836.1 growth arrest-specific protein 7 isoform b
NM_201433.2 NP_958839.1 growth arrest-specific protein 7 isoform c

GAS7 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (9 - 58)

WW

WW: WW domain (79 - 108)

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (203 - 296)

  • 0
  • 100
  • 200
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  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

growth arrest-specific protein 7

GAS7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
GAS7 O60861 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
Intra
GAS7 O60861 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GAS7 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70208 GAS7 Protein, Human (His) O60861-1 (M1-I412) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Glaucoma, Primary Open Angle

  • Glaucoma 1, Open Angle, E

  • Primary Open Angle Glaucoma

  • POAG

  • Adult-Onset Primary Open Angle Glaucoma

  • Chronic Simple Glaucoma

  • GLC1E

  • Primary Open Angle Glaucoma 1e

  • Glaucoma, Open Angle, Primary
Glaucoma, Normal Tension

  • Low Tension Glaucoma

  • Glaucoma, Normal Tension, Susceptibility To

  • Normal Tension Glaucoma

  • Ntg

  • Glaucoma, Normal Pressure

  • NPG

  • Glaucoma, Normal Pressure, Susceptibility To

  • Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Primary Angle-Closure Glaucoma

  • Primary Angle Closure Glaucoma

  • Angle Closure Glaucoma

  • Acg - [Angle Closure Glaucoma]

  • Angle-Closure Glaucoma

  • Closed Angle Glaucoma

  • Acute Glaucoma

  • Prodromal Angle Closure Glaucoma
Open-Angle Glaucoma

  • Glaucoma Simplex

  • Pigmentary Glaucoma

  • Wide-Angle Glaucoma

  • Glaucoma, Open-Angle

  • Open Angle Glaucoma

  • Glaucoma Open-Angle

  • Chronic Simple Glaucoma

  • Coag - [Chronic Open-Angle Glaucoma]

  • Csg - [Chronic Simple Glaucoma]

  • Poag - [Primary Open-Angle Glaucoma]

  • Oag - [Open-Angle Glaucoma]

  • Chronic Glaucoma

  • Chronic Open Angle Glaucoma

  • Simple Glaucoma

  • Chronic Noncongestive Glaucoma

  • Ltg - [Low Tension Glaucoma]

  • Noncongestive Glaucoma

  • Nonobstructive Glaucoma

  • Normal Pressure Glaucoma

  • Primary Low Tension Glaucoma

  • Low-Tension Glaucoma

  • Residual Stage Low Tension Glaucoma

  • Open Cleft Glaucoma
Phacogenic Glaucoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-164456 AMI-408 Inhibitor / Unkown
HY-RS05286 GAS7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07401 KMT2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19133 Gas7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25623 Gas7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GAS7 VGNC VGNC:72886
Mus musculus GAS7 MGD MGI:1202388
Felis catus GAS7 VGNC VGNC:62470
Bos taurus GAS7 VGNC VGNC:29262
Canis familiaris GAS7 VGNC VGNC:41119
Rattus norvegicus GAS7 RGD RGD:621550
Others GAS7 NCBI