SLC13A2 - solute carrier family 13 member 2 Gene

Also Known as NaCT; NADC1; SDCT1; NaDC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9058

About SLC13A2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,473,644-28,497,781 (from NCBI)

This gene has 6 transcripts (splice variants), 254 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 49.7), small intestine (RPKM 41.0) and 4 other tissues.

Summary

The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of Cyclophilin B. The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016]

SLC13A2 Products (4)

mRNA Protein Name
NM_001145975.2 NP_001139447.1 solute carrier family 13 member 2 isoform a
NM_001346683.2 NP_001333612.1 solute carrier family 13 member 2 isoform d
NM_001346684.2 NP_001333613.1 solute carrier family 13 member 2 isoform e
NM_003984.4 NP_003975.1 solute carrier family 13 member 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
enables fumarate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sodium:dicarboxylate symporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
enables succinate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
Biological Process GO Annotation Evidence Références Source
involved in alpha-ketoglutarate transport IDA
IDA: Inferred from direct assay
10894787 GOA
involved in cellular response to lithium ion IDA
IDA: Inferred from direct assay
10894787 GOA
involved in fumarate transport IDA
IDA: Inferred from direct assay
10894787 GOA
involved in succinate transmembrane transport IDA
IDA: Inferred from direct assay
10894787 GOA
Cellular Component GO Annotation Evidence Références Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
27927654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC13A2 Protein Structure

Na_sulph_symp

Na_sulph_symp: Sodium:sulfate symporter transmembrane region (6 - 565)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

solute carrier family 13 member 2

  • Na(+)-coupled citrate transporter

SLC13A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SLC13A2 Q13183 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC13A2 Q13183 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC13A2 Q13183 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SLC13A2 Q13183 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SLC13A2 Q13183 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrolithiasis, Uric Acid

  • Nephrolithiasis, Uric Acid, Susceptibility To

  • Uric Acid Urolithiasis

  • Uric Acid Nephrolithiasis

  • UAN

  • Acute Urate Nephropathy

  • Urolithiasis, Uric Acid

  • Urolithiasis, Uric Acid, Susceptibility To

  • Uric Acid Renal Calculus
Developmental And Epileptic Encephalopathy 25

  • Developmental And Epileptic Encephalopathy, 25

  • Dee25

  • Developmental And Epileptic Encephalopathy 25, With Amelogenesis Imperfecta

  • Early Infantile Epileptic Encephalopathy 25

  • Encephalopathy, Epileptic, Early Infantile, Type 25
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Hyperoxaluria, Primary, Type Ii

  • Primary Hyperoxaluria Type 2

  • D-Glycerate Dehydrogenase Deficiency

  • Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency

  • HP2

  • Oxalosis Ii

  • Glyceric Aciduria

  • L-Glyceric Aciduria

  • Primary Hyperoxaluria, Type Ii

  • Oxalosis 2

  • Hyperoxaluria Primary 2

  • Hyperoxaluria Primary Type Ii

  • Ph2

  • Primary Hyperoxaluria Type Ii
Sialolithiasis

  • Sialolith

  • Stone Of Salivary Gland Or Duct

  • Salivary Gland Calculi

  • Salivary Gland Stone

  • Calculus Of Salivary Gland Or Duct

  • Calculus Of Salivary Gland

  • Salivary Calculus

  • Salivary Gland Calculus

  • Salivary Stone

  • Salivary Duct Calculi

  • Sialodocholithiasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13006 SLC13A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC13A2 VGNC VGNC:65197
Rattus norvegicus SLC13A2 RGD RGD:61920
Macaca mulatta SLC13A2 VGNC VGNC:99256
Canis familiaris SLC13A2 VGNC VGNC:46228
Bos taurus SLC13A2 VGNC VGNC:34674
Mus musculus SLC13A2 MGD MGI:1276558
Others SLC13A2 NCBI