PF-06817024
PF-06817024 is a high affinity, humanized antibody that binds IL-33. PF-06817024 binds to IL-33, prevents IL-33 from binding to receptor ST2, and inhibits downstream type 2 inflammatory responses. PF-06817024 can be used for the research of allergic diseases.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human
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ST2 |
PF-06817024 binds with high, specific affinity to human and cynomolgus monkey IL-33 variants[1].
PF-06817024 potently neutralizes IL-33 activity in human mast cells with an IC50 of 64 pM[1].
PF-06817024 neutralizes IL-33 activity in human whole blood, human peripheral blood mononuclear cells, and IL-33 receptor-overexpressing recombinant cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | CL | Vss | T1/2 |
|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 300 mg/kg | i.v. | 0.058 mL/h/kg | 56 mL/kg | 432 h |
IL-33
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Danto SI, et al. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF-06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study. J Clin Pharmacol. 2024;64(5):529-543. [Content Brief]
[2]. Danto SI, et al. Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis. Allergy Asthma Clin Immunol. 2024;20(1):46. Published 2024 Aug 30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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