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Cat. No.: HY-182446

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SRI-22818

SRI-22818 is a NF-κB activator with an EC₅₀ of 0.5 μM. SRI-22818 upregulates the expression of NF-κB and promotes its activation. SRI-22818 increases the level of SOD2. SRI-22818 exhibits activity in the SOD1^G93Amodel of amyotrophic lateral sclerosis (ALS). SRI-22818 can be used for research related to amyotrophic lateral sclerosis.

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CAS No.: 1429221-68-0
Formule: C₁₆H₁₂BrNO₃
Masse moléculaire:346.18

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Please store the product under the recommended conditions in the Certificate of Analysis.

SRI-22818 Chemical Structure

CAS No.: 1429221-68-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	EC₅₀	0.5 μM Compound: Example 1	Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfected with pNFkappaB-Luc plasmid measured after 24 hrs by Bright-Glo luciferase assay Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfected with pNFkappaB-Luc plasmid measured after 24 hrs by Bright-Glo luciferase assay	[PMID: 31857831]

In Vitro

SRI-22818 increases the expression and activation of NF-κB as well as the level of SOD2 in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1429221-68-0
Masse moléculaire 346.18
Formule C₁₆H₁₂BrNO₃
SMILES

BrC(C=CC=C1)=C1N/C=C\C(C2=CC=C(OCO3)C3=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mathew B, et al. Development of novel small molecules for the treatment of ALS. Bioorg Med Chem Lett. 2020;30(4):126950. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SRI-22818

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SRI-22818 Related Classifications

HY-182446 Related Classifications