Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark

  • Phytomedicine. 2010 Feb;17(2):149-51. doi: 10.1016/j.phymed.2009.05.016.
M J Chavan  1 ,  P S Wakte ,  D B Shinde
Affiliations
  • 1. Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner S.K. 422 608, Dist- Ahmednagar, M.S., India.
PMID: 19576741 DOI: 10.1016/j.phymed.2009.05.016
Abstract

Caryophyllene oxide was isolated from an unsaponified petroleum ether extract of the bark of Annona squamosa and studied for its analgesic and anti-inflammatory activity. Caryophyllene oxide at the doses of 12.5 and 25mg/kg body wt. and unsaponified petroleum ether extract at a dose of 50mg/kg body wt. showed significant central as well as peripheral analgesic, along with anti-inflammatory, activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments.

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