Tylophora compounds as Na+/K(+)-ATPase inhibitors

  • Gen Pharmacol. 1993 Sep;24(5):1107-13. doi: 10.1016/0306-3623(93)90357-4.
J N Gnabre  1 ,  J L Pinnas ,  R B Bates ,  D P Dolata ,  S Gangwar
Affiliations
  • 1. Health Sciences Center, University of Arizona, Tucson, AZ 85724.
PMID: 8270169 DOI: 10.1016/0306-3623(93)90357-4
Abstract

1. Acetyltylophoroside (AcT) and tylogenin inhibit Na+/K(+)-ATPase in spite of having structures very different from cardiac glycosides (CGs). 2. Calculation of the lowest energy conformations of AcT and tylogenin and superpositions of these with the X-ray conformations of CGs and chlormadinone acetate led to a model for the interaction of these different types of Na+/K(+)-ATPase inhibitors with the receptor.

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