Pkia - protein kinase inhibitor, alpha Gene

Also Known as PKIalpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18767

Summary

Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Acts upstream of or within negative regulation of nitrogen compound metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pkia Products (8)

mRNA Protein Name
NM_001410515.1 NP_001397444.1 cAMP-dependent protein kinase inhibitor alpha
NM_001410516.1 NP_001397445.1 cAMP-dependent protein kinase inhibitor alpha
NM_001410520.1 NP_001397449.1 cAMP-dependent protein kinase inhibitor alpha
NM_001410524.1 NP_001397453.1 cAMP-dependent protein kinase inhibitor alpha
NM_001410525.1 NP_001397454.1 cAMP-dependent protein kinase inhibitor alpha
NM_001410526.1 NP_001397455.1 cAMP-dependent protein kinase inhibitor alpha
NM_001410527.1 NP_001397456.1 cAMP-dependent protein kinase inhibitor alpha
NM_008862.4 NP_032888.1 cAMP-dependent protein kinase inhibitor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP-dependent protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
9218452 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23458248 MGI
enables protein kinase A catalytic subunit binding IPI
IPI: Inferred from physical interaction
1862342 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
7836431 MGI
acts upstream of or within negative regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
9218452 MGI
acts upstream of or within negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
9218452 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9218452 MGI
acts upstream of or within regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
7836431 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7836431 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7836431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-dependent protein kinase inhibitor alpha

  • PKI-alpha

Pkia Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pkia P63248 Prkaca Mus musculus P05132
X-Ray Diffraction
23458248
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10598 PKIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkia NCBI NCBI:5569