KHNYN - KH and NYN domain containing Gene

Also Known as KIAA0323

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23351

About KHNYN

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,423,165-24,441,843 (from NCBI)

This gene has 6 transcripts (splice variants), 100 orthologues and 6 paralogues. Ubiquitous expression in stomach (RPKM 18.8), small intestine (RPKM 18.4) and 25 other tissues.

Summary

The protein encoded by this gene contains a ribonuclease NYN domain and belongs to the N4BP1 family. The protein is a cofactor for the zinc finger Antiviral protein (ZAP protein) which targets viral RNA for degradation and restricts SARS-CoV-2 Infection. [provided by RefSeq, Sep 2021]

KHNYN Products (3)

mRNA Protein Name
NM_001290256.2 NP_001277185.1 protein KHNYN isoform 2
NM_001290257.2 NP_001277186.1 protein KHNYN isoform 1
NM_015299.3 NP_056114.1 protein KHNYN isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30659753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KHNYN Protein Structure

RNase_Zc3h12a

RNase_Zc3h12a: Zc3h12a-like Ribonuclease NYN domain (437 - 588)

  • 0
  • 200
  • 400
  • 600
  • 678 a.a.
Protein Preferred Names Protein Names

protein KHNYN

KHNYN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KHNYN O15037 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
KHNYN O15037 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
KHNYN O15037 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
KHNYN O15037 NEDD8 Homo sapiens Q15843
ITC
30659753
Intra
KHNYN O15037 NEDD8 Homo sapiens Q15843
Pull Down
30659753
Intra
KHNYN O15037 NEDD8 Homo sapiens Q15843
Anti Tag CoIP
30659753
Intra
KHNYN O15037 NEDD8 Homo sapiens Q15843
NMR
30659753
Intra
KHNYN O15037 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra
KHNYN O15037 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra
KHNYN O15037 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
KHNYN O15037 PLOD3 Homo sapiens O60568
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07241 KHNYN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KHNYN VGNC VGNC:30544
Rattus norvegicus KHNYN RGD RGD:1565688
Felis catus KHNYN VGNC VGNC:63080
Canis familiaris KHNYN VGNC VGNC:42339
Mus musculus KHNYN MGD MGI:2451333
Macaca mulatta KHNYN VGNC VGNC:73866
Others KHNYN NCBI